The exploration research in the Khoshoomi region, located at the north east (~180km) of Yazd has shown that the area is benfitted from a good uranium reservation. After leaching the samples, the concentration of uranium was evaluated to be 1200±20 mg/l. By solvent extraction, stripping, precipitation and calcination processes, the uranium oxide (U3O8) was produced. The purity and recovery percentages of U3O8 were 70% and 85%, respectively, which are acceptable according to the international documents. It is concluded that the organic phase, containing 3% (vol) Alamine 336+2% (vol) normal dodecanol in aliphatic kerosene, has a good capability for separation of uranium from anomaly no. 6, of Khoshoomi region sulfuric acid leaching solutions. Applying Mc Cabe-Thiele method, with 2 counter current extraction stages, and 2 stripping stages (15% w/v) sodium bicarbonate solution), separation of uranium is feasible. The percentage of recovery, purity of product and feasibility of the chemical processes show that Khoshoomi mine is capable for producing uranium oxide (U3O8). For stablishing a new uranium mine at this region, however a more technical and engineering information is needed.