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Paper Information

Journal:   JOURNAL OF MEDICINAL PLANTS   DECEMBER 2007 , Volume 6 , Number 24; Page(s) 17 To 21.
 
Paper: 

EFFECT OF BLACK PEPPER, RED PEPPER AND ZATARIA MULTIFLORA BOISS. ALCOHOLIC EXTRACTS ON GROWTH AND DNASE ACTIVITY OF STAPHYLOCOCCUS AUREUS

 
 
Author(s):  ZARIN GHALAM MOGHADAM M., SATARI MORTEZA*, ZARIN GHALAM MOGHADAM JALAL, REZAZADEH SH.A.
 
* DEPARTMENT OF BACTRIOLOGY, MEDICAL SCIENCES SCHOOL, TARBIAT MODARRES UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Background: Staphylococcus aureus is one of the most frequently identified pathogens in clinical laboratories and DNase is its important virulence factor. This enzyme is capable of destroying deoxyribonucleic acid (Willett etal., 1988). There are lots of antibacterial agents that can prevent the production of this enzyme. Staphylococcus aureus can develop drug resistance to many chemical drugs so; considerable effort has been expanded by investigators in the development of herbal drugs. Black pepper, Red pepper and Zataria multiflora Boiss. are some herbal drugs that have been used in cure of infections.

Objectives: In this study, the alcoholic extract of Black pepper, Red pepper and Zataria multiflora Boiss. was tested for antibacterial activity against Staphylococcus aureus.

Methods: Black pepper, Red pepper and Zataria multiflora Boiss. were provided from Iranian agricultural researches center.2gr of each plant powder was added to10cc ethanol 96o. After 24 hours, the crude extract was separated as an alcoholic extract and concentrated by distillation method.

Results: The antibacterial activity against Staphylococcus aureus was examined and the results showed that all the extracts were effective. The extracts that showed antimicrobial activity were later tested to determine the Minimum Inhibitory Dilution (MID) for Staphylococcus aureus. They were also effective on the inhibition of DNase activity. The inhibition against DNase activity was observed at the dilutions lower than the minimum inhibitory dilution (MID) of each extract.
Conclusion: The results of this study showed that Black pepper, Red pepper and Zataria multiflora Boiss. extracts can play a significant role in inhibition of Staphylococcus aureus and they can inhibit release of the DNase enzyme.

 
Keyword(s): STAPHYLOCOCCUS AUREUS, DNASE ACTIVITY, BLACK PEPPER, RED PEPPER, ZATARIA MULTIFLORA BOISS
 
References: 
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