Click for new scientific resources and news about Corona[COVID-19]

Paper Information

Journal:   JOURNAL OF MEDICINAL PLANTS   DECEMBER 2007 , Volume 6 , Number 24; Page(s) 38 To 43.
 
Paper: 

EVALUATION OF ANTIDEPRESSANT EFFECT OF ETHANOLIC AND AQUEOUS EXTRACTS OF SILYBUM MARIANUM L. SEED IN MICE

 
 
Author(s):  KARIMI GH.*, SARADEGHI KEYSARI M.
 
* DEPARTMENT OF PHARMACODYNAMY AND TOXICOLOGY, FACULTY OF PHARMACY, MASHHAD
 
Abstract: 

Background: Depression is one of the most psychiatric disorders that there are many treatments for it. Milk thistle is a plant which has many pharmacologic effects such as antioxidant, anti-inflammatory and anticancer. It is reported that silymarin (main component of milk thistle) increase the concentration of some neurotransmitter in brain.

Objective: Evaluation of the antidepressant effect of aqueous and ethanolic extracts of milk thistle.

Methods: We investigated the antidepressant effect of aqueous (0.72, 1.26, 1.80 g/kg) and ethanolic (0.24, 0.42, 0.6 g/kg) extracts using modified forced swimming test in mice.

Results: The ethanolic extract did not have any effect on the duration of immobility of mice. However, the aqueous extract significantly reduced the duration of immobility versus the control group.
Conclusion: Aqueous extract of milk thistle showed antidepressant effect in animal model.

 
Keyword(s): ANTIDEPRESSANT, MODIFIED FORCED SWIMMING TEST, MILK THISTLE, SILYMARIN
 
 
References: 
  • Not Registered.
  •  
  •  
 
Citations: 
  • Not Registered.
 
+ Click to Cite.
APA: Copy

KARIMI, G., & SARADEGHI KEYSARI, M. (2007). EVALUATION OF ANTIDEPRESSANT EFFECT OF ETHANOLIC AND AQUEOUS EXTRACTS OF SILYBUM MARIANUM L. SEED IN MICE. JOURNAL OF MEDICINAL PLANTS, 6(24), 38-43. https://www.sid.ir/en/journal/ViewPaper.aspx?id=104888



Vancouver: Copy

KARIMI GH., SARADEGHI KEYSARI M.. EVALUATION OF ANTIDEPRESSANT EFFECT OF ETHANOLIC AND AQUEOUS EXTRACTS OF SILYBUM MARIANUM L. SEED IN MICE. JOURNAL OF MEDICINAL PLANTS. 2007 [cited 2021July25];6(24):38-43. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=104888



IEEE: Copy

KARIMI, G., SARADEGHI KEYSARI, M., 2007. EVALUATION OF ANTIDEPRESSANT EFFECT OF ETHANOLIC AND AQUEOUS EXTRACTS OF SILYBUM MARIANUM L. SEED IN MICE. JOURNAL OF MEDICINAL PLANTS, [online] 6(24), pp.38-43. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=104888.



 
 
Persian Abstract Yearly Visit 62
 
 
Latest on Blog
Enter SID Blog