Paper Information

Journal:   IRANIAN JOURNAL OF PEDIATRICS   OCTOBER 2007 , Volume 17 , Number 2 (SUPPLEMENT); Page(s) 155 To 160.
 
Paper:  ANTIBIOTIC SUSCEPTIBILITY PATTERNS IN H. INFLUENZAE TYPE B ISOLATED FROM HEALTHY CHILDREN OROPHARYNX IN DAY CARE CENTERS OF TEHRAN
 
Author(s):  FAHIMZAD S.A.R., KARIMI ABD ELAH*, ALBORZI A.A.V., TABATABAEI RAFIEI SEDIGHEH, JADALI F., SHARIFIAN MOSTAFA
 
* PEDIATRICS INFECTIOUS DISEASES RESEARCH CENTER, MOFID CHILDREN’S HOSPITAL, DR SHARIATI AVE, TEHRAN, IR IRAN
 
Abstract: 

Objective: Haemophilus influenzae type b (Hib) is a most frequent cause of invasive diseases such as meningitis, septic arthritis and pneumonia in children under 5 years old. Asymptomatic oropharyngeal colonization is an origin of distribution of microorganism to others and probable bacteremia in the same child. The aim of this study was to determine antibiotic susceptibility of Hib in Tehran day care centers.

Material & Methods: Hib was isolated from oropharynx of 1000 children visiting 25 day care centers selected randomly in different parts of Tehran city during second half of year 2005. For antibiotic susceptibility determination we used disk diffusion test.

Findings: Ampicillin resistance% and Beta lactamase was 32.3 production was seen in 23.6%. Cephalosporins resistance except for cefixime was between 10% to 20% and in cefixime was 58.8%. Rifampin resistance was 17.6%. Resistance to studied macrolids including azythromycin and clarythromycin was 19.6% and 35.3%.

Conclusion: On the base of high antibiotic resistance to Hib in our study and other similar studies in Iran, we recommend to use optimal effective and proper antibiotics to decrease the high rate of antibiotics resistance to Hib colonization and its invasive diseases.

 
Keyword(s): HAEMOPHILUS INFLUENZA, ANTIBIOTIC SUSCEPTIBILITY, OROPHARYANGEAL COLONIZATION, ANTIBIOTIC RESISTANCE
 
References: 
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