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Paper Information

Journal:   MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)   JULY 2006 , Volume 20 , Number 2; Page(s) 52 To 56.
 
Paper: 

CYTOKINE PATTERN IN SERA AND BRONCHO-ALVEOLAR LAVAGE SIX MONTHS AFTER SINGLE EXPOSURE TO SULFUR MUSTARD

 
 
Author(s):  AHMADI KAZEM*, SOLGUE GH.
 
* DEPARTMENT OF IMMUNOLOGY, FACULTY OF MEDICINE AND RESEARCH CENTER OF MOLECULAR BIOLOGY
 
Abstract: 

Background: Cytokines play a major role in both acute and chronic inflammatory processes, including those produced by Sulfur Mustard. This study describes the cytokine level six months after exposure to a single dose of sulfur mustard, defined by IL-1b, IL-6, IL-9, IL-12, TGFb and TNF-a. Methods: The cytokine levels of Broncho-Alveolar Lavage (BAL) and sera of twenty male rats exposed to sulfur mustard were measured and compared with the control group. The rats in the test group were exposed to a single dose of sulphur mustard (inhalation) and left for up to 6 months. After six months the animals were anesthetised, blood samples were obtained from their heart using 5-mL syringes and serum was kept at -20°C. Their BAL was collected by lavage. BAL fluid was centrifuged and left at -20°C until assay. Cytokine assay was performed employing the ELISA Method (Bender Med Systems).
Results: The results showed significant differences (p<0.001) between the control and exposed groups in terms of all cytokine (IL-9, YIFN, TGFβ, IL-6, IL-1
b, IL-12 and TNFα) productions in both the BAL fluid and serum. The most noticeable increase in cytokine release was seen in IL-9, which was 615.93% and 321.88% for the BAL fluid and serum, respectively (p<0.001). After IL-9 the highest increase was demonstrated for TGF-b and IL-6 in the BAL fluid which was 200.85% and 125.50% respectively.
Conclusions: From data presented here, it is possible to suggest that overproduction of IL-6, IL-9 and TGF
b might be involved in the late outcome of lung injury after six months exposure to sulfur mustard.

 
Keyword(s): SULFUR MUSTARD, BAL, CYTOKINE, SERUM, IL-1BETA, IL-6, IL-9, IL-12, TGFBETA AND TNF-ALFA
 
 
References: 
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Citations: 
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APA: Copy

AHMADI, K., & SOLGUE, G. (2006). CYTOKINE PATTERN IN SERA AND BRONCHO-ALVEOLAR LAVAGE SIX MONTHS AFTER SINGLE EXPOSURE TO SULFUR MUSTARD. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 20(2), 52-56. https://www.sid.ir/en/journal/ViewPaper.aspx?id=104426



Vancouver: Copy

AHMADI KAZEM, SOLGUE GH.. CYTOKINE PATTERN IN SERA AND BRONCHO-ALVEOLAR LAVAGE SIX MONTHS AFTER SINGLE EXPOSURE TO SULFUR MUSTARD. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI). 2006 [cited 2021August04];20(2):52-56. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=104426



IEEE: Copy

AHMADI, K., SOLGUE, G., 2006. CYTOKINE PATTERN IN SERA AND BRONCHO-ALVEOLAR LAVAGE SIX MONTHS AFTER SINGLE EXPOSURE TO SULFUR MUSTARD. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), [online] 20(2), pp.52-56. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=104426.



 
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