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Paper Information

Journal:   JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY   2006 , Volume - , Number 3 (38); Page(s) 1 To 6.
 
Paper: 

PREPARATION AND QUALITY CONTROL OF RADIOLABELLED COBALT-57 BLEOMYCINS FOR ONCOLOGICAL STUDIES

 
 
Author(s):  JALILIAN AMIR REZA*, ROUSHAN FARZAD P., MOAFIAN J., ENSAF M.R., SABET MAHSHID
 
* AGRICULTURAL, MEDICAL AND INDUSTRIAL RESEARCH SCHOOL, NUCLEAR SCIENCE AND TECHNOLOGY RESEARCH INSTITUTE, AEOI, KARAJ, IRAN
 
Abstract: 

[55Co] bleomycin has been widely used in oncological studies. Due to relative short half life of cobalt-55, optimization and feasibility studies for determination of the best labeling conditions is preferably performed using cobalt-57. In this study, the optimization of complexation conditions for time, temperature and ligand concentration were performed. The best labeling yield was obtained at room temperature in pH of 4-7, using 0.4 mCi of 57CoCl2 with 0.3mg of BLM in 30 minutes. The final radiopharmaceutical solution underwent common quality control tests, validating our future studies for animal scanning studies using [55Co] bleomycin complex.

 
Keyword(s): COBALT-57, CYCLOTRON, QUALITY CONTROL, BLEOMYCIN, LABELLED COMPOUNDS, SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY (SPECT)
 
References: 
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