Paper Information

Journal:   TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)   NOVEMBER 2007 , Volume 65 , Number 8; Page(s) 14 To 21.
 
Paper: 

CLINICAL OUTCOMES OF PERCUTANEOUS CORONARY INTERVENTION WITH DRUG ELUTING STENTS IN DIABETIC PATIENTS

 
 
Author(s):  PEDARZADEH A., KASAEIAN S.E.*, ESFAHANIAN F., GOUDARZINEZHAD H.R., PAIDARI N., SALARIFAR M., HAJI ZEYNALI A.M., ALI DOUSTI M., BOROUMAND M.A.
 
* TEHRAN HEART CENTER, JALAL AL AHMAD & NORTH KAREGAR CROSS
 
Abstract: 

Background: Several randomized controlled trials have demonstrated the safety and efficacy of drug eluting stents (DES) in selected groups of patients with less complicated diabetes. We conducted this study to determine how an unselected group of diabetic patients in Iran fare following DES implantation.
Methods: Data were collected on 147 consecutive diabetic patients who underwent percutaneous coronary intervention (PCI) with the implantation of at least one DES at the Tehran Heart Center from June 2003 to September 2005. Clinical follow-up was performed by timely scheduled visits at one, four and nine months following DES implantation. Nine months of follow-up was completed for 94.5% of the patients. The primary endpoint was the occurrence of major adverse cardiac events (MACE), which include cardiac death, myocardial infarction and target vessel revascularization (TVR). In-hospital complications were the secondary endpoint.
Results: A total of 158 coronary artery lesions were treated with DES in 147 diabetic patients (mean age = 56.4±8.92 years, 57.1% were men). During the nine-month follow up, MACE occurred in 3.4% of patients, with a myocardial infarction rate of 1.4% and TVR rate of 1.4%. Considering one patient who underwent TVR due to acute stent thrombosis following angioplasty (during hospitalization) the total number of TVR reached 3 (2%). Only one patient (0.7%) died of cardiac death, which occurred after the procedure and before discharge. In-hospital complications occurred in six patients (4.1%); five patients suffered from myocardial infarction. Conclusions: PCI with DES seems to be safe and effective in diabetic patients. However, more studies with larger study populations and longer follow-up are required to confirm this issue.

 
Keyword(s): DIABETES, DRUG ELUTING STENT, PERCUTANEOUS CORONARY INTERVENTION, MAJOR ADVERSE CARDIAC EVENT, TARGET VESSEL REVASCULARIZATION
 
References: 
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