Paper Information

Journal:   JOURNAL OF NUCLEAR SCIENCE AND TECHNOLOGY   2006 , Volume - , Number 2 (37); Page(s) 10 To 16.
 
Paper: 

DOSIMETRY OF 186RE RADIOISOTOPE IN INTRAVASCULAR BRACHYTHERAPY TO REDUCE VASCULAR RESTENOSIS

 
 
Author(s):  POURBEYGI H.*, SHEYBANI SH., GHAFORIAN HOSSEIN, GHAHRAMANI M.R.
 
* DEPARTMENT OF NUCLEAR RESEARCH CENTER, AEOL, TEHRAN, IRAN
 
Abstract: 

Recently, the use of filled angioplasty balloon with radioactive solution was proposed as one of the new intravascular irradiation techniques to reduce restenosis. Measurement of dose distribution beyond an angioplasty balloon filled with 186Re-perrhenatewas carried out using a radiochromic film. The measured dose rate in distance of 0.4mm from the balloon surface (with diameter 4mm and length of 40mm) was 2.07 [(cGy/min)/(mCi/ml)]. Calculation of dose was carried out for the balloons with various size, using Monte-Carlo method with MCNP4B code and the result was comparable with the experimental results. Suitable specific concentrations for delivery of doses from 12 to 20 Gy in vessel wall were obtained 250 to 400(mCi/ml) in the time of irradiation less than 4min and the fall of radial dose was obtained approximately 80 percent in radial distance of 0.5mm from the balloon surface. The internal dose was calculated by MIRD method with assuming that in the case of balloon rupture, 186Re-DTPAcontents were released into the circulation system and was about 0.0027 cGy/MBq which is comparable with the 99mTc-DTP Amodel. Therefore, using from 186Re-DTPA is suitable due to the radiation safety and the delivery of dose in order to reduce restenosis for the coronary vessels with centric cross section.

 
Keyword(s): DOSIMETRY, RESTENOSIS, RADIOCHROMIC FILM, MONTE-CARLO METHOD, INTRAVASCULAR BRACHYTHERAPY, INTERNAL DOSIMETRY
 
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