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Paper Information

Journal:   JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2007 , Volume 14 , Number 2 (31); Page(s) 30 To 35.
 
Paper: 

STUDY OF SHIGELLA GENERA AND THEIR DRUG RESISTANCE IN DYSENTERIC PATIENTS

 
 
Author(s):  ZIAEI MASOUD*, AZARKAR S.GH., SAADATJOU S.A.R., NAMAEI M.H.
 
* DEPARTMENT OF SOCIAL MEDICINE, FACULTY OF MEDICINE, BIRJAND UNIVERSITY OF MEDICAL SCIENCES, BIRJAND, IRAN
 
Abstract: 

Background and Aim: Bloody diarrhea (dysentery) is one of the acute gastrointestinal diseases and Shigellosis is an important cause of it in our country. Variety of its causing agents (Shigella strains) and occurrence of drug resistance have made troubles in selecting of appropriate antibiotics for the treatment of shigellosis. The current study was aimed at identifying different strains of shigella and assessing their drug resistance in the urban and rural regions of Nehbandan.
Materials and Methods: In this quasi experimental study 140 patients presented with acute bloody diarrhea referring to the rural and urban health centers and health houses of Nehbandan were studied. Their stool samples were cultured and underwent antibiogram tests after being carried to a Birjand medical diagnostic laboratory. Cultures were prepared according to WHO standard protocols on Eosin Methylen Blue (EMB) and Shigella - salmonella agar (SS) media. Drug susceptibility was done using disk diffusion method. The obtained data was analyzed by Chi-square and Fisher test, and P≤0.05 was considered as the significant level.
Results: 35 (25%) out of 140 patients were positive regarding shigellosis. The most frequent shigella serotypes were shigella Flexneri in 30 cases (85.7%), shigella Boydii in 4 cases (11.4%) and shigella Sonnei in 1 case (2.9%). All shigella strains were sensitive to Ciprofloxacin and Nalidixic acid, but 85.7% to Cefixime. Only 20% of shigella strains were sensitive to Co-trimoxazole.
Conclusion: According to the study, using Nalidixic acid is recommended as the first line of treatment in shigellosis due to low price, few side effects and availability in health centers.

 
Keyword(s): DYSENTERY, SHIGELLOSIS, SHIGELLA, DRUG RESISTANT, ANTIBIOTIC
 
References: 
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