Paper Information

Journal:   IRANIAN JOURNAL OF PUBLIC HEALTH   2008 , Volume 37 , Number 1; Page(s) 31 To 34.
 
Paper: 

FREQUENCY OF PFCRT T76 AND PFDHFR ASN-108 DRUG RESISTANCE MUTATIONS IN FALCIPARUM MALARIA IN SOUTHEASTERN MALARIA ENDEMIC AREA OF IRAN

 
Author(s):  RAZAVI M.R., NADAF S.R., BRAS J.L.E., RAEISI A., ESMAEILI RASTAGHI A.R., ASMAR M.*
 
* DEPT. OF PARASITOLOGY, PASTEUR INSTITUTE OF IRAN, PASTEUR AVE., TEHRAN, IRAN
 
Abstract: 

Background: Point mutations in the genes, Pfcrt and Pfdhfr, have been identified elsewhere as strongly associated with resistance to chloroquine (CQ) and pyrimethamine, respectively.
Methods: Using a restriction digestion method, we report the frequency of two important mutations, T76 and Asn108, responsible for conferring resistance to chloroquine and pyrimethamine, respectively, in patients residing in malarious areas of southeastern Iran.
Results: Ninety eight and 84% of the patients were found to harbor chloroquine resistant (theronine-76) and pyrimethamine resistant (aspargin-108) mutants, respectively.
Conclusions: Despite the high frequency of T76 and Asn 108 mutations in Iranian patients, combination of CQ and pyrimethamine-sulfadoxine (SP) was shown to be quite successful with 100% adequate clinical and parasitological responses.

 
Keyword(s): MALARIA, DRUG RESISTANCE, CHLOROQUINE, PYRIMETHAMINE/SULFADOXINE, IRAN
 
References: 
 
  pdf-File tarjomyar Yearly Visit 48
 
Latest on Blog
Enter SID Blog