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Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   MARCH 2008 , Volume 7 , Number 1 ; Page(s) 37 To 40.
 
Paper: 

IL-1, IL-1R AND TNFALPHA GENE POLYMORPHISMS IN IRANIAN PATIENTS WITH MULTIPLE SCLEROSIS

 
 
Author(s):  SARIAL SH., SHOKRGOZAR M.A., AMIRZARGAR ALI AKBAR, SHOKRI F., RADFAR J., ZOHREVAND P., ARZHANG Z., SAHRAEIAN M.A., LOTFI J.
 
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Abstract: 

Different research groups have extensively studied the associations of cytokine gene polymorphisms in different diseases. The role of cytokines gene polymorphisms in multiple sclerosis (MS), as a chronic Immune-mediated neurodegenerative disease, has been previously reported in the various populations.

For determining pro-inflammatory cytokine gene polymorphisms, 100 relapsing remitting multiple sclerosis (RRMS) Iranian patients and 140 normal individuals as control enrolled in this study. DNA of each sample was extracted by a modified salting out method. Cytokine single gene nucleotide polymorphisms including IL-1a -889, IL-1b (-511 and +3962), IL-1R pst1 1970, IL-1RA mspal 11100, and TNF-a (-308 and -238) were determined by using the PCR-SSP method.

The results of our data indicate the decrease in frequency of IL-1a TC-889 genotype (p=0.002), IL-1b TC +3962 genotype (p=0.004), IL-1R T pst1 1970 allele (p= 0.0001), IL-1 RA TC Mspa1 11100 genotype (p=0.009), TNF-a A-308 allele (p=0.0002) and AG genotype (p=0.00001) in the patients group versus normal subjects. On the other hand the frequency of IL-1a TT -889 genotype (p=0.028), IL-1R C pst1 1970 allele (p=0.0001) and CC genotype (p=0.00006), TNFa G -308 allele (p=0.0002) and GG genotype (p=0.000001) decreased significantly in the patients versus normal subjects.
These results suggest that polymorphic variations of these pro-inflammatory cytokines may play an important role in susceptibility of Iranian multiple sclerosis patients.

 
Keyword(s): CYTOKINES, IL-1, TNFALPHA, GENE POLYMORPHISM, MULTIPLE SCLEROSIS, SINGLE NUCLEOTIDE POLYMORPHISM
 
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