Paper Information

Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   MARCH 2008 , Volume 7 , Number 1 ; Page(s) 31 To 36.
 
Paper: 

THYROID FUNCTION AND ANTI-THYROID ANTIBODIES IN IRANIAN PATIENTS WITH TYPE 1 DIABETES MELLITUS: INFLUENCES OF AGE AND SEX

 
 
Author(s):  SHARIFI FARANAK*, GHASEMI LEYLA, MOUSAVINASAB S.N.A.D.
 
* ZANJAN METABOLIC DISEASES RESEARCH CENTER, VALI-E- ASR HOSPITAL, ZANJAN, IRAN
 
Abstract: 

Type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (ATD).Genetic susceptibility for autoantibody formation in association with ATD and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about its prevailing situation in Iran.

We have therefore investigated the prevalence of anti-thyroid peroxidase (anti-TPO) and anti thyroglubolin (Anti TG) antibodies in type 1 diabetic patients, and compared the effect of age and sex on the thyroid autoimmunity in patients with type 1 diabetes mellitus in Iran.

Ninety one subjects with type 1 diabetes mellitus and one hundred and sixty three unrelated normal controls under the age of thirty years were recruited for the detection of anti-TPO and anti-TG. Radio Immuno Assay and chemiluminescence methods were used for anti-TPO and anti-TG detection respectively.

Among 91 type 1 diabetic patients, 36 (39.6%) were positive for anti-TPO and 27(30%) were positive for antiTG. Anti-TPO antibodies were detected only in 6.7% of control group. Comparing with those without thyroid autoimmunity, there was a female preponderance for the type 1 diabetic patients with thyroid autoimmunity (female: male, 28:14 vs. 28:20 respectively). Among the type 1 diabetic patients those with thyroid autoimmunity, tended to be older (p: 0.04) and to have higher TSH concentration (p: 0.03). Patients with high anti-TPO levels had longer duration of diabetes (P: 0.02).
The presence of anti-TPO in 39.6% of our type 1 diabetic patients comparing with 8.5% of normal subjects confirmed the strong association of ATD and type 1 diabetes mellitus.

 
Keyword(s): AUTOIMMUNE THYROID DISEASE, ANTI-TPO, ANTI-TG, DIABETES TYPE 1, DIABETES MELLITUS, IRANIAN PATIENTS
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 63
 
Latest on Blog
Enter SID Blog