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Paper Information
Journal:   IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)   MARCH 2008 , Volume 7 , Number 1 ; Page(s) 19 To 24.
 
Paper: 

DETERMINATION OF HLA-B27 SUBTYPES IN IRANIAN PATIENTS WITH ANKYLOSING SPONDYLITIS
 
 
Author(s):  NIKNAM M.H.*, MAHMOUDI MAHDI, AMIRZARGAR ALI AKBAR, GANJ ALI KHANI HAKEMI M., KHOSRAVI F., JAMSHIDI AHMAD REZA, AMIRKHANI A., ANSARIPOUR B., POURPAK Z., MOEIN M., NIKBIN B.
 
* MOLECULAR IMMUNOLOGY RESEARCH CENTER, FACULTY OF MEDICINE, UNIVERSITY OF TEHRAN, POURSINA AVE, POSTAL CODE: 1417613151, TEHRAN, IRAN
 
Abstract: 

The human leukocyte antigen-B27 is one of the class I molecules of the major histocompatibility complex which is strongly associated with ankylosing spondylitis (AS). The strength of the disease association with B27 varies markedly among racial and ethnic populations. It is an allele family, which constitutes about 31 subtypes, with a considerable geographic and ethnic difference in distribution. It is important to know whether certain subtypes show any preferential association with AS. Because there is no report regarding HLA-B27 subtypes in Iranian patients with AS, the main purpose of the present study was to assess the frequency of subtypes of human leukocyte antigen (HLA)-B27 in patients with ankylosing spondylitis in Iranian population.

One hundred and nineteen AS patients (82 HLA-B27 positive and 37 HLA-B27 negative) were selected for this study. HLA-B27 positive patients were screened by polymerase chain reaction amplification with sequence-specific primers (PCR-SSP) for B*27 subtyping.

The results of present study revealed that only two subtypes were detected in Iranian patients, including B*2705 (52 patients, 63.4%) and B*2702 (30 patients, 36.6%).

Our results showed a restricted number of HLA-B27 subtypes associated with AS in Iran and an elevated frequency of the B*2705 allele in these patients similar to other Euro-Caucasoid (Aryan) groups in the world.
 
Keyword(s): ANKYLOSING SPONDYLITIS, HUMAN LEUKOCYTE ANTIGEN, HLA-B27 SUBTYPES, IRAN
 
 
References: 
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Cite:
APA: Copy

NIKNAM, M., & MAHMOUDI, M., & AMIRZARGAR, A., & GANJ ALI KHANI HAKEMI, M., & KHOSRAVI, F., & JAMSHIDI, A., & AMIRKHANI, A., & ANSARIPOUR, B., & POURPAK, Z., & MOEIN, M., & NIKBIN, B. (2008). DETERMINATION OF HLA-B27 SUBTYPES IN IRANIAN PATIENTS WITH ANKYLOSING SPONDYLITIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 7(1), 19-24. https://www.sid.ir/en/journal/ViewPaper.aspx?id=103763



Vancouver: Copy

NIKNAM M.H., MAHMOUDI MAHDI, AMIRZARGAR ALI AKBAR, GANJ ALI KHANI HAKEMI M., KHOSRAVI F., JAMSHIDI AHMAD REZA, AMIRKHANI A., ANSARIPOUR B., POURPAK Z., MOEIN M., NIKBIN B.. DETERMINATION OF HLA-B27 SUBTYPES IN IRANIAN PATIENTS WITH ANKYLOSING SPONDYLITIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI). 2008 [cited 2021April11];7(1):19-24. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103763



IEEE: Copy

NIKNAM, M., MAHMOUDI, M., AMIRZARGAR, A., GANJ ALI KHANI HAKEMI, M., KHOSRAVI, F., JAMSHIDI, A., AMIRKHANI, A., ANSARIPOUR, B., POURPAK, Z., MOEIN, M., NIKBIN, B., 2008. DETERMINATION OF HLA-B27 SUBTYPES IN IRANIAN PATIENTS WITH ANKYLOSING SPONDYLITIS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), [online] 7(1), pp.19-24. Available at: <https://www.sid.ir/en/journal/ViewPaper.aspx?id=103763>.
 
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