Paper Information

Journal:   ACTA MEDICA IRANICA   SEPTEMBER-OCTOBER 2007 , Volume 45 , Number 5; Page(s) 345 To 350.
 
Paper: 

HUMORAL AND CELLULAR IMMUNITY PARAMETERS IN CHILDREN BEFORE AND AFTER ADENOTONSILLECTOMY

 
 
Author(s):  BARADARANFAR M.H.*, DOUDANGEH F., TAGHIPOUR ZAHIR SH., ATAR M.
 
* DEPARTMENT OF OTOLARYNGOLOGY AND HEAD AND NECK SURGERY, SCHOOL OF MEDICINE, YAZD UNIVERSITY OF MEDICAL SCIENCES, YAZD, IRAN
 
Abstract: 

Adenoids and tonsils are active lymphoid organs and play an important role against invading antigens of upper aerodigestive tract in children. The present study analyzes the changes in cellular and humoral immunity of children six months after adenotonsillectomy. The study population consisted of 30 children whit chronic adenotonsillar hypertrophy and 30 age-matched healthy children. In all children serum level of IgM and IgG, percentage of T lymphocytes (CD3), T helper cells (CD4), T cytotoxic cells (CD8) and B lymphocytes (CD20) were measured before surgery. These parameters were remeasured in patients 6 months after adenotonsillectomy. Before the operation, a reduction in percentage of T lymphocytes (CD3),TCD4,TC8 and B CD20 was seen compared to control group. This reduction was only significant in T lymphocytes (CD3).The serum IgM and IgG levels were not different in two groups. Six months after operation, the percentage of lymphocytes T CD3, T CD8 and BCD20 was increased and reached the control group. The IgM level was also significantly decreased in patients after operation. Our results indicate that cellular and humoral immunity decreases in children with chronic adenotonsiller hypertrophy preoperatively and increases to healthy children level, six months postoperatively. It means that chronic adenotosillar hypertrophy affect some parameters of cellular and humoral immunity and adenotonsillectomy by removing chronic stimulations and reverses these changes without any negative effect on immune function of patients.

 
Keyword(s): ADENOTONSILLECTOMY, IMMUNE SYSTEM, LYMPHOCYTES
 
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