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Paper Information

Journal:   PHYSIOLOGY AND PHARMACOLOGY   SPRING 2007 , Volume 11 , Number 1; Page(s) 10 To 18.
 
Paper: 

THE ROLE OF GALANIN RECEPTORS IN ANTICONVULSANT EFFECT OF LOW FREQUENCY STIMULATIONS ON ACQUISITION OF PERFORANT PATH KINDLED SEIZURES IN RATS

 
 
Author(s):  SADEGH M., MIRNAJAFIZADEH S.J.*, JAVAN M., FATH ELAHI Y., MOHAMMADZADEH MOHAMMAD, JAHANSHAHI A., ESLAMIFAR A., DEL JOU Z.
 
* DEPT. PHYSIOLOGY, SCHOOL OF MEDICAL SCIENCES, TARBIAT MODARES UNIV., TEHRAN, IRAN
 
Abstract: 
Introduction: Low-frequency stimulation (LFS) has a delaying effect on kindled seizures acquisition. In the present study we examined the role of galanin receptors in the inhibitory effects of LFS on kindled seizures induced by electrical stimulation of perforant path.
Methods: Animals were stimulated daily at the AD threshold intensity with a rapid kindling procedure. LFS was applied immediately after cessation of each kindling stimulation. M35 (0.5 and 1.0 nM per site), a nonselective galanin receptor antagonist, was microinjected daily into the dentate gyrus before the beginning of stimulation protocol and behavioral seizure stages and after discharge durations were recorded.
Results: LFS application had a suppressive effect on the kindling rate. It significantly increased the number of stimulations needed to reach seizure stages 3, 4 and 5. LFS also decreased the cumulative after discharge duration during the days of stimulation. Intra-dentate gyrus microinjection of M35 reduced the inhibitory effect of LFS on kindling rate, significantly.
Conclusion: These data indicate that galanin receptors may have a role in mediating part of the inhibitory effects of LFS on perforant path kindled seizures.
 
Keyword(s): SEIZURE, LOW FREQUENCY STIMULATION, GALANIN, DENTATE GYRUS, RAPID KINDLING
 
References: 
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