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Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   2008 , Volume 16 , Number 1; Page(s) 51 To 54.
 
Paper: 

DETERMINATION OF PLASMA GLUTHATIONE REDUCTASE ENZYME ACTIVITY IN OSTEOPOROTIC WOMEN

 
 
Author(s):  SADEGHI N., OVEYSI M.R., HAJI MAHMOUDI MANAN, SAJADIAN Z., JANAT B., JAMSHIDI A.R.
 
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Abstract: 

Background: Osteoporosis is a disease of high prevalence with increased bone loss. Free radicals have been proved to be involved in bone resorption. Glutathione reductase (GR) plays an essential role in cell defense against reactive oxygen metabolites by sustaining the reduced status of an important antioxidant, glutathione. In the present study GR activity of plasma as an antioxidant enzyme in relation to Bone Mineral Density (BMD) was investigated.
Material and Method: GR activity was measured spectrophotometrically at 339 nm in 138 women. Participants were selected by inclusion and exclusion criteria from those who were referred to Jamie Clinic in Tehran for BMD evaluation.
Results: Plasma activity of GR (Mean± SD) was: 64.44 ± 37.68 U/L in the control group, 75.49 ± 54.84 U/L in the total patients [(mild Osteopenia + severe Osteopenia and Osteoporosis) (Tscore<-1)] and 80.48 ± 61.91 U/L in the patients with severe Osteopenia and Osteoporosis respectively (Tscore <-1.7).
Conclusion: The results show that plasma activity of GR in patients with bone deficiency was higher than the control group. The difference was more pronounced between controls and the patients with severe Osteopenia and Osteoporosis, than those differences between controls and the total patients. Femur Tscore adjustment with age and BMI showed significant negative correlation with the plasma activity of GR in all subjects.

 
Keyword(s): ANTIOXIDANT, GLUTATHIONE REDUCTASE, PLASMA, OSTEOPOROSIS
 
 
References: 
 
Click to Cite.
APA: Copy

SADEGHI, N., & OVEYSI, M., & HAJI MAHMOUDI, M., & SAJADIAN, Z., & JANAT, B., & JAMSHIDI, A. (2008). DETERMINATION OF PLASMA GLUTHATIONE REDUCTASE ENZYME ACTIVITY IN OSTEOPOROTIC WOMEN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 16(1), 51-54. https://www.sid.ir/en/journal/ViewPaper.aspx?id=103540



Vancouver: Copy

SADEGHI N., OVEYSI M.R., HAJI MAHMOUDI MANAN, SAJADIAN Z., JANAT B., JAMSHIDI A.R.. DETERMINATION OF PLASMA GLUTHATIONE REDUCTASE ENZYME ACTIVITY IN OSTEOPOROTIC WOMEN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE. 2008 [cited 2021May11];16(1):51-54. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103540



IEEE: Copy

SADEGHI, N., OVEYSI, M., HAJI MAHMOUDI, M., SAJADIAN, Z., JANAT, B., JAMSHIDI, A., 2008. DETERMINATION OF PLASMA GLUTHATIONE REDUCTASE ENZYME ACTIVITY IN OSTEOPOROTIC WOMEN. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, [online] 16(1), pp.51-54. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103540.



 
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