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Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   2008 , Volume 16 , Number 1; Page(s) 9 To 12.
 
Paper: 

SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NEW N,N-DIARYL-4-(4,5-DICHLOROIMIDAZOLE-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXAMIDES

 
 
Author(s):  AMINI MOHSEN, NAVID POUR L., SHAFIEI A.*
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, FACULTY OF PHARMACY AND PHARMACEUTICAL SCIENCES RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN,14174, IRAN
 
Abstract: 

Background and the purpose of the study: Dihydropyridines having carboxamides in 3 and 5 positions show anti-tuberculosis activity. The purpose of the present study was to synthesize new DHPs having possible anti-tuberculosis activity.
Methods: 4,5-Dichloroimidazole-2-carboxaldehyde was condensed with N-arylacetoacetamides and ammonium acetate in methanol to give N,N-diaryl-4-(4,5-dichloroimidazole-2-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxamides. All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv).
Results and major conclusion: Some of the new synthesized compounds exhibited a moderate activity in comparison to rifampicin.

 
Keyword(s): ANTITUBERCULOSIS, DIHYDROPYRIDINE, DICHLOROIMIDAZOLE
 
 
References: 
 
Citations: 
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APA: Copy

AMINI, M., & NAVID POUR, L., & SHAFIEI, A. (2008). SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NEW N,N-DIARYL-4-(4,5-DICHLOROIMIDAZOLE-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXAMIDES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 16(1), 9-12. https://www.sid.ir/en/journal/ViewPaper.aspx?id=103511



Vancouver: Copy

AMINI MOHSEN, NAVID POUR L., SHAFIEI A.. SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NEW N,N-DIARYL-4-(4,5-DICHLOROIMIDAZOLE-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXAMIDES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE. 2008 [cited 2021June12];16(1):9-12. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103511



IEEE: Copy

AMINI, M., NAVID POUR, L., SHAFIEI, A., 2008. SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NEW N,N-DIARYL-4-(4,5-DICHLOROIMIDAZOLE-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXAMIDES. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, [online] 16(1), pp.9-12. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103511.



 
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