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Paper Information

Journal:   DARU JOURNAL OF PHARMACEUTICAL SCIENCE   2008 , Volume 16 , Number 1; Page(s) 9 To 12.
 
Paper: 

SYNTHESIS AND ANTITUBERCULAR ACTIVITY OF NEW N,N-DIARYL-4-(4,5-DICHLOROIMIDAZOLE-2-YL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXAMIDES

 
 
Author(s):  AMINI MOHSEN, NAVID POUR L., SHAFIEI A.*
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, FACULTY OF PHARMACY AND PHARMACEUTICAL SCIENCES RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN,14174, IRAN
 
Abstract: 

Background and the purpose of the study: Dihydropyridines having carboxamides in 3 and 5 positions show anti-tuberculosis activity. The purpose of the present study was to synthesize new DHPs having possible anti-tuberculosis activity.
Methods: 4,5-Dichloroimidazole-2-carboxaldehyde was condensed with N-arylacetoacetamides and ammonium acetate in methanol to give N,N-diaryl-4-(4,5-dichloroimidazole-2-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxamides. All compounds were screened for their antitubercular activity against Mycobacterium tuberculosis (H37Rv).
Results and major conclusion: Some of the new synthesized compounds exhibited a moderate activity in comparison to rifampicin.

 
Keyword(s): ANTITUBERCULOSIS, DIHYDROPYRIDINE, DICHLOROIMIDAZOLE
 
References: 
 
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