Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   FALL 2006 , Volume 24 , Number 82; Page(s) 14 To 20.
 
Paper: 

THE COMPARISON OF THE EFFECT OF VITAMIN D2 AND VITAMIN D3 ON ATHEROSCLEROSIS IN AORTA AND CORONARY ARTERIES OF MALE RATS

 
 
Author(s):  MANSOURI AZAM, FAGHIHI MEHRI, VAHDATI A., AFROUZ T.
 
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Abstract: 

Introduction: Atherosclerosis is an age-related disease but conditions such as increased cholesterol intake, cigarette smoking and positive family history may be associated with premature atherosclerosis. Since rats do not have a high tendency for progression of atherosclerosis in response to cholesterol-rich diet, the overdose prescription of vitamin D2 and D3 as atherogenic agents can stimulate calcium sedimentation in the process of atherogenesis. The aim OF this study was to investigate the effects of varying dosages of vitamin D2 and Vitamin D3 on atherosclerotic lesions of aorta and coronary arteries in male rats.

Methods: Twenty Wistar rats weighing approximately 200±20 g were divided into four groups. The experiment was conducted in two 6-week phases. During the first phase one of groups was selected as control and was given the base diet. One group received daily %2 cholest erol, %0.5 cholic acid+Base food another group received daily cholesterol-rich diet+300000 IU/kg vitamin D3+ base food, and the last group received daily cholesterol-rich diet+3000 IU/kg+base food. The first blood test conducted six weeks after the start of the experiment confirmed the hypercholesterolemic status of the animals. The second phase of the experiment continued for six weeks with the same diet as the first phase. At the conclusion of the second phase of the experiment, samples were taken from the aorta and coronary arteries of the animals and the tissue lesions in the aorta and coronary arteries were examined. In this study, variance and Duncan tests were performed using SPSS. Statistical significance was taken as P<0.05.

Results: Examination of tissue samples did not reveal any lesions in the group treated with vitamin D2+ cholesterol-rich diet and in the group treated with cholesterol-rich diet without vitamin. In the group treated with vitamin D3+cholesterol-rich diet, arteriosclerotic lesions were seen in the media and intima.

Conclusions: Vitamin D3 has atherogenic effects, especially when added to cholesterol-rich diet. However, the atherogenic properties of other dosages of vitamin D2should be investigated.

 
Keyword(s): ATHEROSCLEROSIS, VITAMIN D2, VITAMIN D3,CHOLESTEROL
 
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