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Paper Information

Journal:   ACTA MEDICA IRANICA   MARCH-APRIL 2008 , Volume 46 , Number 2; Page(s) 137 To 140.
 
Paper: 

ASSESSMENT OF FREQUENCY OF ALLOIMMUNIZATION AND ERYTHROCYTE AUTOIMMUNIZATION IN TRANSFUSION DEPENDENT THALASSEMIA PATIENTS

 
 
Author(s):  ANSARI S.*, VOSOUGH PARVANEH, MOSHTAGHIAN S.
 
* DEPARTMENT OF HEMATOLOGY AND ONCOLOGY, ALI ASGHAR CHILDREN'S HOSPITAL, SCHOOL OF MEDICINE, IRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Life-long red blood transfusion remains the main treatment for severe thalassemia. The development of hemolytic alloantibodies and erythrocyte autoantibodies complicated transfusion therapy in thalassemia patients. The frequency causes and prevention of this phenomenon among 80 transfused thalassemia patients were evaluated in Ali Asghar Children’s Hospital during 1998-2004 in a cross-sectional study. In our study the mean age at the initiation of transfusion was 1.7 years (SD=1.94) and mean interval of transfusion 33.73 day (SD=20.74). Autoimmunization in 15 patients was positive and 8 patients had hemolytic reaction in transfusion. Our data show that all immunization to minor erythrocyte antigens and erythrocyte autoimmunization of significant clinical variables, are frequent findings in transfused thalassemia patients. However data suggest that prevalence of immunization in our patients is less than other Asian countries.

 
Keyword(s): TRANSFUSION, THALASSEMIA, ALLOIMMUNIZATION, AUTOIMMUNIZATION, COOMB’S TEST, HEMOLYTIC REACTION
 
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