Paper Information

Journal:   RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)   WINTER 2008 , Volume 14 , Number 57; Page(s) 15 To 20.
 
Paper: 

DETERMINATION OF LACTIC DEHYDROGENASE LEVEL IN CEREBROSPINAL FLUID IN NEONATES

 
 
Author(s):  EHSANIPOUR F.*, SHABANI M.
 
* HAZRAT-E-RASOOL AKRAM HOSPITAL, NIAYESH ST., SATTARKHAN AVE., IRAN UNIVERSITY OF MEDICAL SCIENCES AND HEALTH SERVICES, TEHRAN, IRAN
 
Abstract: 

Background & Aim: Levels of lactic dehydrogenase(LDH) in the cerebrospinal Fluid(CSF) have been used to evaluate a variety of neurologic disorders. However, few studies have been performed on neonates. The aim of this study was to detect levels of this enzyme in normal neonates.
Patients and Methods: In this descriptive study, CSF samples were collected from 94 febrile infants; 46 aged 0-4 weeks and 48 aged 5-8 weeks. These LDH levels were compared to those of 45 febrile infants with mean age of 10±6/2 months who were suspected of nervous system infection and normal CSF findings.
Results: Mean total LDH activity in the CSF was significantly higher in the first month of life than in the second month of life as compared with the control group (p<0.001).
Conclusion: We propose evaluation of total LDH activity in CSF of normal neonates according to age.

 
Keyword(s): CEREBROSPINAL FLUID, LACTIC DEHYDROGENASE, NEONATE
 
References: 
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