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Journal:   ACTA MEDICA IRANICA   NOVEMBER-DECEMBER 2007 , Volume 45 , Number 6; Page(s) 449 To 456.
 
Paper: 

Half-Dose Depot Triptorelin Comparable To Reduced Daily Buserelin: A Randomized Clinical Trial

 
 
Author(s):  Safdarian L., Soltani Mohammadi F., Ale Yasin Ashraf, Aghahosseini M., Meysami A.P., Rahimi E.*
 
* DEPARTMENT OF ANESTHESIOLOGY AND CRITICAL CARE MEDICINE, SCHOOL OF MEDICINE, MEDICAL SCIENCES, UNIVERSITY OF TEHRAN, TEHRAN, IRAN
 
Abstract: 
Pituitary suppression by depot GnRH agonist may be excessive for ovarian stimulation. This study compares the efficacy of a single half-dose depot triptorelin and reduced-dose daily buserelin in a long protocol ICSI/ET. METHODS: A total of 182 patients were randomized into two groups using sealed envelopes. Pituitary desensitization was obtained in group 1 (91 patients) with half-dose (1.87 mg) depot triptorelin in the mid-luteal phase of their menstrual cycle, and in group 2 (91 patients) with standard daily dose (0.5 mg) buserelin, which was then reduced to 0.25 mg at the start of human menopausal gonadotropin (HMG) stimulation. RESULTS: No significant differences were found among those who received HCG in terms of clinical pregnancy rate (34.4% in both groups), implantation rate (14.8% in group 1 versus 11.1% in group 2), fertilization rate (93.3 versus 95.6%), poor response rate (11.1 versus 6.7%), and miscarriage rate (11.1 versus 7.8%). No significant differences were seen in number of HMG ampoules used, follicles at HCG administration, and oocytes retrieved. The number of days of stimulation was significantly reduced in group 2 (11.2 +/- 1.8 in group 1 versus 10.6 +/- 1.9, p = 0.030). CONCLUSION: A  half-dose of depot triptorelin can be successfully used in ovarian stimulation instead of reduced-dose daily buserelin, with more patient comfort and reduced stress and cost of injections.
 
Keyword(s): CONTROLLED OVARIAN STIMULATION, TRIPTORELIN, BUSERELIN
 
 
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APA: Copy

SAFDARIAN, L., & SOLTANI MOHAMMADI, F., & ALE YASIN, A., & AGHAHOSSEINI, M., & MEYSAMI, A., & RAHIMI, E. (2007). HALF-DOSE DEPOT TRIPTORELIN COMPARABLE TO REDUCED DAILY BUSERELIN: A RANDOMIZED CLINICAL TRIAL. ACTA MEDICA IRANICA, 45(6), 449-456. https://www.sid.ir/en/journal/ViewPaper.aspx?id=103343



Vancouver: Copy

SAFDARIAN L., SOLTANI MOHAMMADI F., ALE YASIN ASHRAF, AGHAHOSSEINI M., MEYSAMI A.P., RAHIMI E.. HALF-DOSE DEPOT TRIPTORELIN COMPARABLE TO REDUCED DAILY BUSERELIN: A RANDOMIZED CLINICAL TRIAL. ACTA MEDICA IRANICA. 2007 [cited 2022August09];45(6):449-456. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103343



IEEE: Copy

SAFDARIAN, L., SOLTANI MOHAMMADI, F., ALE YASIN, A., AGHAHOSSEINI, M., MEYSAMI, A., RAHIMI, E., 2007. HALF-DOSE DEPOT TRIPTORELIN COMPARABLE TO REDUCED DAILY BUSERELIN: A RANDOMIZED CLINICAL TRIAL. ACTA MEDICA IRANICA, [online] 45(6), pp.449-456. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103343.



 
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