Paper Information

Journal:   ACTA MEDICA IRANICA   NOVEMBER-DECEMBER 2007 , Volume 45 , Number 6; Page(s) 457 To 460.
 
Paper: 

A PROSPECTIVE RANDOMEZED CONTROLLED TRIAL OF TWO REGIMENS OF VAGINAL ISOPROSTOL IN SECOND TRIMESTER TERMINATION OF PREGNANCY

 
 
Author(s):  ESLAMIAN L.*, GOSILI R., JAMAL A., ALE YASIN ASHRAF
 
* DEPARTMENT OF OBSTETRICS AND GYNECOLOGY, SHARIATI HOSPITAL, MEDICAL SCIENCES, UNIVERSITY OF TEHRAN, TEHRAN, IRAN
 
Abstract: 

The search continues for a safe effective and cheap method for mid-trimester termination of pregnancy. Misoprostol is a strong contender in this respect. The dose schedule is still not fixed. The objective of this study was to compare the efficacy and adverse effects of two dose regimens of vaginal misoprostol for second trimester termination. Prospective randomized double blind controlled trial was undertaken in 162 women at 14-24 weeks gestation in a teaching hospital. Subjects were randomized to receive either regime A: 400 g of intra vaginal misoprostol every 6h, or regime B: 200 g of intravaginal misoprostol every 6h. The main outcome measure was the success rate at 24h, total dose required, induction-abortion interval and adverse effects. Data was analyzed by student’s t-test, Mann Whitney U-test, the chi-squared test or Fisher’s exact test. There was a significant difference in the success rate at 24 and 48hr (regime A: 74% and 97.5%; regime B: 61.7% and 88.9% P=0.016 & 0.029 respectively) and in the mean induction abortion interval (14 Vs 2h, P=0.01) Mean Misoprostol requirement was significantly higher for regime A (731g ± 362g vs. 531g ± 35mgm, P=0.001). Use of 400 g vaginal misoprostol is superior to 200 g vaginal misoprostol for second trimester abortion.

 
Keyword(s): MISOPROSTOL, PREGNANCY, SECOND TRIMESTER ABORTION
 
References: 
  • ندارد
 
  pdf-File tarjomyar Yearly Visit 75
 
Latest on Blog
Enter SID Blog