Paper Information

Journal:   ACTA MEDICA IRANICA   NOVEMBER-DECEMBER 2007 , Volume 45 , Number 6; Page(s) 487 To 492.
 
Paper: 

EVALUATION OF IL1-ALPHA AND TNF-ALPHA SERUM LEVELS IN RHEUMATOID ARTHRITIS PATIONTS WITH ACTIVE AND INACTIVE, WITH OR WITHOUT BONE EROSION

 
 
Author(s):  ROSTAMIAN A.A.R.*, NAJI A.H., GHARIB DOUST F., KHALVAT A., JAFARI SARAF L., SAEIDFAR K.
 
* DEPARTMENT OF REUMATOLOGY, SCHOOL OF MEDICINE, MEDICAL SCIENCES, TEHRAN UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Rheumatoid arthritis is the most common inflammatory joint disease with 1 percent prevalence in community which presents with symmetrical polyarthritis of hands with inflammatory behavior. Several studies in recent years were conducted for evaluation of inflammatory cytokines such as IL1-a (Interleukin 1a) and TNF- a (Tumor necrosis factor) in rheumatologic disorders including rheumatoid arthritis to find new treatment methods base to pathogenesis. In this study different serum levels of IL1-a and TNF- a in 160 rheumatoid arthritis patients with active and inactive disease and also disease with or without bone erosion are assessed. 4% of our patients had rheumatoid nodule and 70% of all patients had positive RF, IL1-a, and TNF- a levels. Active with bone erosion patients had IL1-a and TNF- a serum levels higher than active without bone erosion patients; it was not significant in test but it was significant in Mann-Whitney Test. The results was the same as expected; IL1-a, and TNF- a serum levels were higher in active with bone erosion in comparison with inactive without bone erosion patients.

 
Keyword(s): RHEUMATOID ARTHRITIS, EROSION, CYTOKINS
 
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