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Paper Information

Journal:   ACTA MEDICA IRANICA   NOVEMBER-DECEMBER 2007 , Volume 45 , Number 6; Page(s) 443 To 448.
 
Paper: 

COMPARATIVE EFFICACY OF MISOPROSTOL AND OXYTOCIN AS LABOR PREINDUCTION AGENTS: A PROSPECTIVE RANDOMIZED TRIAL

 
 
Author(s):  ABEDIASL ZH.*, FAROKHI M., RAJAEI MINOU
 
* DEPARTMENT OF OBESTERIC AND GYNECOLOGY, SCHOOL OF MEDICINE, HORMOZGAN UNIVERSITY OF MEDICAL SCIENCE, HORMOZGAN, IRAN
 
Abstract: 

The purpose of this study was to compare the efficacy and safety of misoprostol and oxytocin for induction of labor. In this prospective and randomized controlled trial one hundred twenty women with an unfavorable cervix who underwent labor induction were assigned to receive either intravenous high dose oxytocin(6mIu/min) or intravaginal misoprostol 50+g every 6 hours for two doses. Twelve hours later if labor was not stablished oxytocin induction was initiated per standardized protocol (3mIu/min). Mean Bishop Score change (± SD) over the initial 12 hours interval was significantly greater in the misoprostol group (11.98± 1.55) compared with the oxytocin group (8.83 ± 2.61). There were no statistically significant differences in the median duration of labor ( 449±261.1 min, 514.5±288.5 min, respectively;p=0.22) , the mode of delivery or the adverse maternal /neonatal out come among the two groups.Use of misoprostol as a labor preinduction / labor induction agent results in greater Bishop score changes compared with high dose oxytocin and both of them are comparable.

 
Keyword(s): MISOPROSTOL, OXYTOCIN, CERVICAL RIPENING, LABOR INDUCTION
 
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