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Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   MARCH 2008 , Volume 11 , Number 2; Page(s) 186 To 195.
 
Paper: 

INVARIANT NATURAL KILLER T CELLS IN IMMUNE SURVEILLANCE AND TUMOR IMMUNOTHERAPY: PERSPECTIVES AND POTENTIALS

 
DOI: 

08112/AIM.0012

 
Author(s):  HAERYFAR S.M.M.*
 
* ASSISTANT PROFESSOR, DEPARTMENT OF MICROBIOLOGY AND IMMUNOLOGY, SCHULICH SCHOOL OF MEDICINE AND DENTISTRY, THE UNIVERSITY OF WESTERN ONTARIO, LONDON, ONTARIO N6A 5C1, CANADA
 
Abstract: 

Although various elements of the immune system are involved in detection and elimination of neoplastic cells, immune surveillance mechanisms are not always successful in eradicating cancer. Invariant natural killer T cells are potent immunomodulatory lymphocytes that secrete large amounts of Th-1 and/or Th-2 cytokines in response to glycolipid agonists. The observed role of invariant natural killer T cells in antitumor immunity in various animal models and the relatively recent identification and availability of Invariant natural killer T cell glycolipid ligands with anticancer properties such as α-galactosylceramide have led to several invariant natural killer T cell-based clinical trials in cancer patients with somewhat promising outcomes. The objective of this article is to provide a short overview on immunobiology of invariant natural killer T cells followed by their potential applications in treatment of cancer.

 
Keyword(s): Α-GALACTOSYLCERAMIDE, ANTITUMOR IMMUNITY, IMMUNOTHERAPY, NKT CELLS
 
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