Paper Information

Journal:   ARCHIVES OF IRANIAN MEDICINE   MARCH 2008 , Volume 11 , Number 2; Page(s) 166 To 172.
 
Paper: 

EFFECT OF LITHIUM ON SWIM STRESS-INDUCED ANTINOCICEPTION IN NAIVE MICE AND MICE WITH SUBCHRONIC ADMINISTRATION OF MORPHINE OR SWIM STRESS IN FORMALIN TEST

 
DOI: 

08112/AIM.009

 
Author(s):  FAZLI TABAEI S., BAZAZ N., MODIRZADEH A., MAGHSOUDI A., ZARINDAST M.R.*
 
* DEPARTMENT OF PHARMACOLOGY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Background: Lithium has been shown to relieve mania and induce antinociception. In the present study, swim stress at 8°C induced antinociception in both phases of the formalin test. Intraperitoneal administration of lithium chloride (LiCl) (0.05, 0.25, and 0.5 mg/kg) also induced antinociception in both phases of the formalin test.
Methods: Antinociception was assessed by the formalin test method. Swim stress was achieved in the 8°C water in a container 5 cm in diameter and 20 cm tall filled with water do a depth of 11 cm.
Results: The drug (0.5 and 5 mg/kg) potentiated swim stress-induced antinociception in the second phase of the test. Repeated exposure to water swimming stress with a period of 40 sec, once daily for three days, in combination with lithium chloride did not alter stress-induced antinociception in either phases of the formalin test, when swim stress-induced antinociception was tested on the fourth day. Subchronic treatment with morphine (25 mg/kg), once daily for three days, in the presence or absence of lithium chloride (5 mg/kg) did not alter swim stress-induced antinociception, either, when swim stress-induced antinociception was tested on the fourth day.
Conclusion: It may be concluded that lithium chloride potentiates swim stress-induced antinociception, but the drug has no influence on the response of subchronic administration swim stress or morphine.

 
Keyword(s): DEXTROMETHORPHAN, FORMALIN TEST, MICE, SWIM STRESS-INDUCED ANTINOCICEPTION, TOLERANCE
 
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