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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES   WINTER 2007 , Volume 3 , Number 1; Page(s) 51 To 56.
 
Paper: 

DETERMINATION OF GLYCYRRHETIC ACID IN RAT PLASMA BY HPLC AFTER ORAL ADMINISTRATION OF LICORICE AQUEOUS EXTRACT

 
 
Author(s):  SHAMSA F.*, SOURI E., JALALIZADEH H., FARZAMI P., SHARIFZADEH M.
 
* DEPTARTMENT OF MEDICINAL CHEMISTRY, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

Licorice is obtained from Glycyrrhiza glabra (G. glabra) in Iran. Glycyrrhizin is the main constituent of G. glabra and has several pharmacological effects. It is hydrolyzed to glycyrrhetic acid (GA) in the intestine after oral administration. In this study, a novel HPLC method was used to determine the concentration of GA in rat plasma after oral administration of licorice aqueous extract. The method was linear (r2 >0.999) in the range of 0.1-5.0 mg/ml for GA. Maximum plasma concentration of GA was achieved 8 h after oral administration of licorice aqueous extract. The developed method was suitable for determination of GA in rat plasma.

 
Keyword(s): GLYCYRRHETIC ACID, GLYCYRRHIZIN, HPLC, LICORICE, PLASMA
 
 
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APA: Copy

SHAMSA, F., & SOURI, E., & JALALIZADEH, H., & FARZAMI, P., & SHARIFZADEH, M. (2007). DETERMINATION OF GLYCYRRHETIC ACID IN RAT PLASMA BY HPLC AFTER ORAL ADMINISTRATION OF LICORICE AQUEOUS EXTRACT. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 3(1), 51-56. https://www.sid.ir/en/journal/ViewPaper.aspx?id=103245



Vancouver: Copy

SHAMSA F., SOURI E., JALALIZADEH H., FARZAMI P., SHARIFZADEH M.. DETERMINATION OF GLYCYRRHETIC ACID IN RAT PLASMA BY HPLC AFTER ORAL ADMINISTRATION OF LICORICE AQUEOUS EXTRACT. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2007 [cited 2021May16];3(1):51-56. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103245



IEEE: Copy

SHAMSA, F., SOURI, E., JALALIZADEH, H., FARZAMI, P., SHARIFZADEH, M., 2007. DETERMINATION OF GLYCYRRHETIC ACID IN RAT PLASMA BY HPLC AFTER ORAL ADMINISTRATION OF LICORICE AQUEOUS EXTRACT. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, [online] 3(1), pp.51-56. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103245.



 
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