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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES   WINTER 2007 , Volume 3 , Number 1; Page(s) 43 To 50.
 
Paper: 

SPECTROPHOTOMETRIC DETERMINATION OF TROPICAMIDE IN BULK AND PHARMACEUTICAL FORMULATIONS

 
 
Author(s):  AMANLOU M.*, SOURI E., IZADI SHIVA, FARSAM H.
 
* DEPARTMENT OF MEDICINAL CHEMISTRY, FACULTY OF PHARMACY, AND PHARMACEUTICAL SCIENCES RESEARCH CENTER, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN, IRAN
 
Abstract: 

A simple and sensitive extractive spectrophotometric method is described for determination of tropicamide. The method is based on the reaction of tropicamide and bromocresol green. The ion-paired colored complex was extracted with chloroform at pH 3. The extracted complex showed maximum absorbance at 423 nm. The complex was stable up to 2 days and obeyed Beer's law over the concentration ranges of 1.32-100.81 mg/ml. No significant interference was observed from the excipients, coloring and flavoring agents commonly used in the tropicamide pharmaceutical preparations. The proposed method was applied successfully for determination of tropicamide in commercial eye drop dosage forms.

 
Keyword(s): BROMOCRESOL GREEN, ION-PAIR COMPLEX, SPECTROPHOTOMETRY, TROPICAMIDE
 
References: 
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