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Paper Information

Journal:   ACTA MEDICA IRANICA   JANUARY-FEBRUARY 2008 , Volume 46 , Number 1; Page(s) 27 To 32.
 
Paper: 

OCCULT HEPATITIS B VIRUS INFECTION AMONG BLOOD DONORS WITH ANTIBODIES TO HEPATITIS B CORE ANTIGEN

 
 
Author(s):  JAFARZADEH A.*, KAZEMI ARABABADI M., MIRZAEI M., POURAZAR A.
 
* DEPARTMENT OF IMMUNOLOGY, SCHOOL OF MEDICINE, RAFSANJAN UNIVERSITY OF MEDICAL SCIENCES, RAFSANJAN, IRAN
 
Abstract: 

Diagnosis of hepatitis B is routinely based on of serological assay of hepatitis B surface antigen (HBsAg). Occult hepatitis B virus (HBV) infection is generally defined as the detection of HBV-DNA in the serum or tissues of subjects who have negative test for HBsAg. Transmission of HBV infection has been documented from HBsAg negative, anti-HBc positive blood and organ donors. The aim of this study was to determine the rate of occult HBV infection among HBsAg negative and anti- HBc positive blood donors of Rafsanjan blood transfusion center. Sera from 270 healthy blood donors who were negative for both HBsAg and anti-HCV, were tested for anti-HBc antibodies by use of ELISA technique. The samples that were negative for HBsAg but positive for anti-HBc markers also examined for the presence of HBV-DNA by polymerase chain reaction (PCR). Out of 270 HBsAg negative blood samples, 14 samples (5.18%) were positive for anti-HBc antibodies. HBV-DNA was detected in 4/14 (28.57%) of HBsAg negative and anti-HBc positive samples. Moreover, anti-HBs antibody was detected in 2/4 (50%) of HBV-DNA positive samples. These results indicated that HBVDNA found in the majority of HBsAg negative and anti-HBc-positive donors. In addition, the present study recommend the incorporation of routine anti-HBc screening of blood as a surrogate marker of occult HBV infection to prevent some transfusion-transmitted HBV infections.

 
Keyword(s): HEPATITIS B VIRUS INFECTION, BLOOD DONORS, ANTI-HBC ANTIBODY, HBV-DNA
 
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