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Paper Information

Journal:   IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES   WINTER 2007 , Volume 3 , Number 1; Page(s) 25 To 30.
 
Paper: 

INVOLVEMENT OF GABAERGIC SYSTEM IN INCREASED PENTYLENETETRAZOLE- INDUCED SEIZURE THRESHOLD IN CHOLESTATIC MICE

 
 
Author(s):  KHAYAT NOURI M.H., BABAPOUR V., SAMINI M.*
 
* DEPARTMENT OF PHARMACOLOGY, FACULTY OF MEDICINE, TEHRAN UNIVERSITY OF MEDICAL SCIENCES, TEHRAN UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

Gamma-aminobutyric acid (GABA) is an important inhibitory transmitter in central nervous system and is involved in pathophysiology of epilepsy. Pentylenetetrazole (PTZ), a convulsant agent, partly acts via anion channel of GABAA receptor. Ivermectin, an antiparasitic agent and a GABAA agonist, has anticonvulsant effect in animal seizure models. Cholestasis increases the threshold of PTZ-induced clonic seizure in mice. The object of this study was to clarify the involvement of GABAergic pathways in increasing PTZ-induced seizure threshold (ST) in cholestatic mice. The result of this study showed that cholestasis increases clonic ST three days after surgery while sham-operated control (SOC) and unoperated control (UOC) groups did not show any alteration in clonic ST. Bicuculline, a GABAA antagonist, reversed but ivermectin increased the clonic ST in UOC, SOC and bile duct-ligated mice, respectively. In conclusion, our results showed that: (1) acute cholestasis is associated with an increase in PTZ-induced clonic ST in mice and this phenomenon may be the result of reinforcement of GABAergic system, and (2) GABA plays a physiological role in regulation of ST.

 
Keyword(s): BICUCULLINE, CHOLESTASIS, GABAERGIC SYSTEM, IVERMECTIN, PTZ-INDUCED SEIZURE THRESHOLD
 
 
References: 
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Click to Cite.
APA: Copy

KHAYAT NOURI, M., & BABAPOUR, V., & SAMINI, M. (2007). INVOLVEMENT OF GABAERGIC SYSTEM IN INCREASED PENTYLENETETRAZOLE- INDUCED SEIZURE THRESHOLD IN CHOLESTATIC MICE. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 3(1), 25-30. https://www.sid.ir/en/journal/ViewPaper.aspx?id=103220



Vancouver: Copy

KHAYAT NOURI M.H., BABAPOUR V., SAMINI M.. INVOLVEMENT OF GABAERGIC SYSTEM IN INCREASED PENTYLENETETRAZOLE- INDUCED SEIZURE THRESHOLD IN CHOLESTATIC MICE. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2007 [cited 2021May11];3(1):25-30. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103220



IEEE: Copy

KHAYAT NOURI, M., BABAPOUR, V., SAMINI, M., 2007. INVOLVEMENT OF GABAERGIC SYSTEM IN INCREASED PENTYLENETETRAZOLE- INDUCED SEIZURE THRESHOLD IN CHOLESTATIC MICE. IRANIAN JOURNAL OF PHARMACEUTICAL SCIENCES, [online] 3(1), pp.25-30. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103220.



 
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