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Paper Information

Journal:   JOURNAL OF ADVANCES IN MEDICAL AND BIOMEDICAL RESEARCH   SUMMER 2007 , Volume 15 , Number 59; Page(s) 9 To 20.
 
Paper: 

THE EFFECT OF REVERSIBLE LOCUS COERULEUS (LC) ON I.V SELF-ADMINISTRATION OF MORPHINE AND MORPHINE WITHDRAWAL SYNDROME (MWS) SIGNS IN RATS

 
 
Author(s):  ESMAEILI M.H.*, GANJKHANI M., MELATI A.A., RASTAK SH.
 
* SCHOOL OF MEDICINE, QAZVIN UNIVERSITY OF MEDICAL SCIENCES, QAZVIN, IRAN
 
Abstract: 

Background and Objective: Locus coeruleus (LC) has been hypothesized to play an important role in a variety of behaviors and opiate withdrawal. This study was designed to determine the effects of reversible inactivation of LC on self-administration of morphine and morphine- withdrawal syndrome signs (MWS).
Materials and Methods: 24 male rats (250-300gr) were surgically implanted bilaterally with cannula in LC then implanted with catheters in the right jugular vein. The rats were tested in 2 groups:Control (saline) and morphine. Morphine group was divided into 3 subgroups: control, sham-operated and LC-inactivated group where they received 1
mL 2% Lidocaine 5 minutes prior to testing. Animals were allowed to self-administer morphine (1mg/infusion) during 10 consecutive days for 2 hours. The number of lever pressing was recorded. At the end of the training day all groups received naloxone (2mg/kg I.P) and MWS were studied for 30 minutes.
Results: LC inactivation prevents the development of tolerance and dependence on morphine and greatly attenuates morphine-withdrawal syndrome.
Conclusion: LC inactivation not only attenuates morphine withdrawal syndrome but also prevents morphine tolerance and dependence in rats.

 
Keyword(s): MORPHINE-WITHDRAWAL SYNDROME, LOCUS COERULEUS, SELF-ADMINISTRATION, RAT
 
References: 
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