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Paper Information

Journal:   HEPATITIS MONTHLY   2007 , Volume 7 , Number 4; Page(s) 183 To 200.
 
Paper: 

ACUTE EXACERBATIONS OF CHRONIC HEPATITIS B ARE ACCOMPANIED BY DECLINE OF CORE ANTIGEN-SPECIFIC REGULATORY T-CELL FREQUENCIES: IMPLICATIONS FOR SUCCESSFUL ANTI-HBV TREATMENTS

 
 
Author(s):  TSAI S.L.*, WANG S.L., FENG I.C., KUO H.T., KOAY L.B., SHEU M.J., LEE CHUAN, SUN C.S., WU K.T., LIN CH.Y.
 
* LIVER RESEARCH UNIT, DEPARTMENT OF MEDICAL RESEARCH, CHI. MEI. MEDICAL CENTER, 901 CHUNG HWA ROAD, YOUNG-KANG CITY, TAINAN, 710 TAIWAN
 
Abstract: 

Background and Aims: Acute exacerbations (AEs) of perinatally-acquired chronic hepatitis B (CHB) are accompanied by increased T cell responses to hepatitis B core and e antigens (HBcAg & HBeAg). Naturally-arising forkhead transcription factor Foxp3 (forkhead box p3)-expressing CD4+CD25+ regulatory T (Treg) cells are thought to be important in the control of infectious diseases. This study aimed to investigate whether HBcAg-specific Treg cells play a role in modulating spontaneous AEs and in influencing the outcome of anti-hepatitis B virus (HBV) treatments.

Methods: The SYFPEITHI scoring system was employed to predict epitope peptides on HBcAg overlapping with HBeAg for the construction of peptide-HLA class II tetramers to measure HBcAg-specific Treg cell frequencies (Treg f).

Results: HBcAg-specific Treg f declined significantly in association with increased HBcAg-specific cytotoxic T lymphocyte frequencies during spontaneous AEs without treatment. Vigorous in vitro expansion of CD4+CD25+Treg cells from CHB patients responding to HBcAg and/or its peptides plus interleukin-2 (IL-2) was consistently detected. Depletion of Treg cells from peripheral blood mononuclear cells enhanced proliferation to HBcAg. In contrast, patients with AEs who received anti-HBV treatments with oral nucleoside analogues or interferon-alpha injection revealed that more post treatment increase of HBcAg-specific Treg f correlated with a higher sustained remission rate to the therapy.

Conclusions: These data indicate that HBcAg-specific Treg cells from perinatally-acquired CHB patients are proliferative to HBcAg and its peptides and exhibit suppressor activity. They play a crucial role in modulating spontaneous AEs and in successful anti-HBV treatments.

 
Keyword(s): CHRONIC HEPATITIS B, ACUTE EXACERBATION, REGULATORY T CELL, SUSTAINED REMISSION
 
 
References: 
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Citations: 
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APA: Copy

TSAI, S., & WANG, S., & FENG, I., & KUO, H., & KOAY, L., & SHEU, M., & LEE, C., & SUN, C., & WU, K., & LIN, C. (2007). ACUTE EXACERBATIONS OF CHRONIC HEPATITIS B ARE ACCOMPANIED BY DECLINE OF CORE ANTIGEN-SPECIFIC REGULATORY T-CELL FREQUENCIES: IMPLICATIONS FOR SUCCESSFUL ANTI-HBV TREATMENTS. HEPATITIS MONTHLY, 7(4), 183-200. https://www.sid.ir/en/journal/ViewPaper.aspx?id=103045



Vancouver: Copy

TSAI S.L., WANG S.L., FENG I.C., KUO H.T., KOAY L.B., SHEU M.J., LEE CHUAN, SUN C.S., WU K.T., LIN CH.Y.. ACUTE EXACERBATIONS OF CHRONIC HEPATITIS B ARE ACCOMPANIED BY DECLINE OF CORE ANTIGEN-SPECIFIC REGULATORY T-CELL FREQUENCIES: IMPLICATIONS FOR SUCCESSFUL ANTI-HBV TREATMENTS. HEPATITIS MONTHLY. 2007 [cited 2021June25];7(4):183-200. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103045



IEEE: Copy

TSAI, S., WANG, S., FENG, I., KUO, H., KOAY, L., SHEU, M., LEE, C., SUN, C., WU, K., LIN, C., 2007. ACUTE EXACERBATIONS OF CHRONIC HEPATITIS B ARE ACCOMPANIED BY DECLINE OF CORE ANTIGEN-SPECIFIC REGULATORY T-CELL FREQUENCIES: IMPLICATIONS FOR SUCCESSFUL ANTI-HBV TREATMENTS. HEPATITIS MONTHLY, [online] 7(4), pp.183-200. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=103045.



 
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