This paper attempts to re-study and re-read into the life of Ala eddine Mahammad-the Sixth Leader of Nazari Assassins-in Iran. He is the man whose life was full of agitation and unrestness because of Melancholia. On the other hand, as an imam, he was in charge of the leadership of Nazari religion and politics. Therefore, his health of mind and spirit have been analyzed from different approaches, this paper is trying to discuss the causes of his mental and spiritual illness both psychologically and sociologically.