Paper Information

Journal:   MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES   SUMMER 2007 , Volume 50 , Number 96; Page(s) 177 To 186.
 
Paper: 

COMPARISON OF IMMUNITY AGAINST RUBELLA BEFORE AND AFTER MEASLES-RUBELLA VACCINATION IN 15-23 YEAR-OLD WOMEN

 
 
Author(s):  MAHMOUDI M.*, VAHEDI E.
 
* IMMUNOLOGY RESEARCH CENTER, BU-ALI RESEARCH INSTITUTE, MASHHAD UNIVERSITY OF
 
Abstract: 

Introduction: Rubella is an exanthematous childhood viral disease that its main importance is because of development of Congenital Rubella Syndrome (CRS) in infants born from non immune mothers infected with rubella, especially in early gestational period. CRS is characterized by hearing defect, cataract, glaucoma, microcephaly, mental rethardation, cardiac anomalies and etc. Measles-Rubella mass campaign was done in late 2003 and 5-25 year-old people were vaccinated. In this study the effect of vaccination on the immunity against rubella was studied.

Material and Methods: This retrospective cross- sectional study was done on women reffered to Central Laboratory of Imam Reza Hospital in 2002-2005. The study included 1698 women (1148 women aged 15-23 years) referred for counseling before vaccination and 354 women (162 women aged 15-23 years) after vaccination. Anti-Rubella IgG concentration was measured by ELlSA method. SPSS 12was used to analyze the data.

Results: Immunity rates were 67.19% (70.38% in 15-23 year-old women) and 77.40% (89.50% in 15-23 year-old women) in women participated in this study before and after vaccination, respectively. Immunity of non-vaccinated women decreases by age increase.
Conclusion: Statistical analysis showed the positive effect of vaccination on immunity status of vaccinated women (Z=5.11, p<0.001). Authors suggest that women older than 25 years should also be included in rubella vaccination program, as well.

 
Keyword(s): RUBELLA, CONGENITAL RUBELLA SYNDROME, VACCINATION, IMMUNITY STATUS
 
References: 
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