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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   FALL 2006 , Volume 24 , Number 82 (SUPPLEMENT); Page(s) 73 To 79.
 
Paper: 

INHIBITION OF PRESSOR RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION WITH PREOXYGENATION

 
 
Author(s):  TALAKOUB R.*, KHALIGHI E., SAGHAEI M.
 
* ANESTHESIOLOGY DEPARTMENT, ALZAHRA UNIVERSITY HOSPITAL, ISFAHAN UNIVERSITY OF MEDICAL SCIENCES (IUMS), ISFAHAN, IRAN
 
Abstract: 

Introduction: Arterial blood pressure and heart rate increase following laryngoscopy and tracheal intubation. This has been referred to as the pressor response which may be harmful in the presence of myocardial or cerebral pathology and necessitate the use of prophylactic measures to control it.
Preoxygenation as a main component of rapid-sequence induction of general anesthesia counteracts the development of hypoxia and can induce a marked inhibition of the pressor response before endotracheal intubation. This study investigates the effect of preoxygenation and also compares it with that of lidocaine on the pressor response to tracheal intubation.
Methods: Seventy-two adult ASA (American Society Anesthesiologists) I patients scheduled for elective operation under general anesthesia and endotracheal intubation were included in this study. The patients were instructed randomly to breath from a fitted facemask of either air or 100% O2 for a period of 5 minutes. Four minutes after facemask application, lidocaine or normal saline as placebo was administered and general anesthesia was induced after one minute.
After intubation, inspiratory gas in air groups was switched to 100% O2. Blood pressure and heart rate were recorded at different times before and after intubation. Statistical analyses were done by using post-hoc, Kruskal-Wallis H, Friedman and chi square tests.
Results: Blood pressure and heart rate increased significantly in air groups at 1 and 2 minutes after endotracheal intubation. The heart rate increased significantly in all groups except in the oxygen + lidocaine group at 1 and 2 minutes after intubation.
Conclusions: The present study introduces a new use of preoxygenation, namely inhibition of the pressor response to laryngoscopy and endotracheal intubation which is comparable to the effect of lidocaine administration. In addition, combination of preoxygenation and lidocaine administration seems to be an ideal means of suppressing the components of the pressor response.

 
Keyword(s): PREOXYGENATION, LIDOCAINE, PRESSOR RESPONSE, LARYNGOSCOPY, INTUBATION
 
 
References: 
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Citations: 
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APA: Copy

TALAKOUB, R., & KHALIGHI, E., & SAGHAEI, M. (2006). INHIBITION OF PRESSOR RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION WITH PREOXYGENATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 24(82 (SUPPLEMENT)), 73-79. https://www.sid.ir/en/journal/ViewPaper.aspx?id=102240



Vancouver: Copy

TALAKOUB R., KHALIGHI E., SAGHAEI M.. INHIBITION OF PRESSOR RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION WITH PREOXYGENATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S). 2006 [cited 2021July28];24(82 (SUPPLEMENT)):73-79. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=102240



IEEE: Copy

TALAKOUB, R., KHALIGHI, E., SAGHAEI, M., 2006. INHIBITION OF PRESSOR RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION WITH PREOXYGENATION. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), [online] 24(82 (SUPPLEMENT)), pp.73-79. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=102240.



 
 
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