Paper Information

Journal:   ADVANCES IN COGNITIVE SCIENCE   SPRING 2007 , Volume 9 , Number 1 (33); Page(s) 1 To 9.
 
Paper: 

THE ROLE OF AMYGDALA GLUTAMATERGIC SYSTEM IN THE ACQUISITION AND EXPRESSION OF MORPHINE-INDUCED PLACE PREFERENCE IN WISTAR RATS

 
 
Author(s):  REZAYOF A.*, GOL HASANI KESHTAN F., NAZARI SORANJEH F., HAERI ROUHANI SEYED ALI
 
* 
 
Abstract: 

Objective: In the present study, the effects of bilateral injections of N-methyl-D-aspartate (NMDA) receptor agonist and/or antagonist into the central amygdala (CeA) on the acquisition and expression of morphine induced conditioned place preference were investigated in male Wista rats.
Method: Male Wistar rats (240-280g) were used in this research. The cannulas were implanted (bilaterally) in the (CeA) by stereotaxic instrument. All animals were allowed 1 week to recover before CPP. Unbiased CPP was induced using a. 5-day schedule consisted of pre-conditioning, conditioning and testing phases.
Results: Animals that had received 3 daily subcutaneous (S.C.) injections of morphine (1-9mg/kg) or saline (1ml/kg) showed a significant preference for compartment paired with morphine in a dose dependent manner. Intra-CeA administration of the NMDA (0.01, 0.1 and 1
mg/rat) with an ineffective dose of morphine (1mg/kg, S.C.) elicited a significant CPP. Administration of the non-competitive NMDA receptor antagonist, MK-801 (0.1, 0.3 and 0.5mg/rat) into the central amygdala inhibited the morphine (6mg/kg, s.c.)-induced place preference in a dose dependent manner. Furthermore, intra-CeA administration of MK-801 (0.25, 0.5 and 1mg/rat) reduced the response induced by NMDA (1mg/rat, intra-CeA) plus morphine (1mg/kg, s.c.). Neither NMDA nor MK-801 alone did produce a significant place preference or place aversion. Moreover, intra-CeA injection of NMDA but not MK-801 before testing significantly increased the expression of morphine (6mg/kg, s.c.)-induced place preference.
Conclusion: These results suggest that the glutamatergic system through the NMDA receptor mechanisms in the central amygdala may play an important role in the acquisition and expression of morphine-induced place preference.

 
Keyword(s): MORPHINE, CONDITIONED PLACE PREFERENCE, CENTRAL AMYGDALA, NMDA, MK-80L, WISTAR RATS
 
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