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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   FALL 2006 , Volume 24 , Number 82 (SUPPLEMENT); Page(s) 67 To 72.
 
Paper: 

PRENATAL STRESS INDUCES IMPAIRMENT OF MEMORY AND REDUCTION IN THE VOLUME OF HIPPOCAMPUS IN RAT

 
 
Author(s):  HOSSEINI SHARIFABAD M.*, SABAHI A.A.R.
 
* DEPARTMENT OF ANATOMY, SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, YAZD, IRAN
 
Abstract: 

Introduction: Prenatal stress may have detrimental effects on hippocampus, leading to memory disorders. However, there is thus far little information on, the, morphometrical alterations of hippocampus in prenatally stressed models. We investigated the effect of prenatal stress on memory function and volumes of the layers of hippocampus in adult rat offspring.
Methods: This experimental study was performed in Yazd University of Medical Sciences and Aarhus University of Denmark from 2002 to 2004. Adult virgin female Wistar rats weighing 220 g were housed with a sexually experienced male Wistar rat. Pregnant rats were randomly assigned to prenatal stress (PS) or control (Cont) groups. Stressed animals were individually restrained in plexiglass tubes for 1 hour, on days 15-21 of gestation. Control pregnant rats were left undisturbed in their home cages. Two male pups were taken from each litter. They were housed and tested at 60 days of age (PS, n=9; Cont, n=8). Memory function was assessed according to passive avoidance test.
Animals were then anesthetized and transcardially perfused with fixative solution. The brains were removed and divided into two hemispheres. The Right hemispheres were selected and 100
mm thick sections were cut with vibratome and were collected along the entire extent of the hippocampus. The Cavalieri principle was used for volume estimation.
Results: A significant reduction in both memory and volume in all layers of the dentate gyrus and CA3 hippocampal field was found in rats exposed to stress in the prenatal period.
Conclusions: Our results provide a neuroanatomical basis that may be relevant to the reported disturbances in behavior and learning in prenatally stressed offspring.

 
Keyword(s): STEREOLOGY, HIPPOCAMPUS, PRENATAL STRESS, MEMORY
 
References: 
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