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Paper Information

Journal:   IRANIAN JOURNAL OF DERMATOLOGY   FALL 2007 , Volume 10 , Number 3 (41); Page(s) 211 To 218.
 
Paper: 

GLI 1 PROTEIN EXPRESSION IN DIFFERENT TYPES OF BASAL CELL CARCINOMA

 
 
Author(s):  ANSARIN H.*, FIROUZEH M., SADEGHIPOUR A.R., TAJZIEH CHI L.
 
* DEPARTMENT OF DERMATOLOGY, RASOUL AKRAM HOSPITAL, TEHRAN, IRAN
 
Abstract: 

Background and aim: Basalcell carcinoma (BCC) is the most common cancer in humans. Activation of Hedgehog (Hh) signal has a key role in development of BCC. The end result of Hedgehog signal is Gli proteing. Gli 1 is a member of this family which activates DNA transcription. Previous studies showed increased expression of Gli 1 in BCC.
Materials and methods: In this study 38 pathologic samples from patients with BCC were evaluated for expression of Gli 1.
Results: In this study Gli 1 was most of time found in the nuclei and its expression was higher in invasive forms of BCC. We did not find any relationship between Gli 1 expression and location, recurrence, age, sexor history of radiotherapy in our patients.
Conclusion: This study confirms the key role of Gli 1 in the pathogenesis of BCC. Gli 1 protein can help us to determine the prognosis.

 
Keyword(s): BASAL CELL CARCINOMA GLI 1 PROTEIN, HEDGEHOG SIGNAL
 
References: 
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