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Paper Information

Journal:   JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)   FALL 2006 , Volume 24 , Number 82 (SUPPLEMENT); Page(s) 38 To 43.
 
Paper: 

RECOMBINANT HUMAN GROWTH HORMONE AND HEALING: DOES GROWTH HORMONE HAVE A POSITIVE EFFECT ON SKIN WOUND HEALING?

 
 
Author(s):  RASTI ARDAKANI M., OMIDIFAR N.*, ANSARI S., GHAHERI H.
 
* 24, SHAHID KHEIR ALLAHI ALLEY, HOSSEIN ABAD ST., ISFAHAN, IRAN, POSTAL CODE: 8175937781
 
Abstract: 

Introduction: Healing of skin defects following trauma, surgery, and chronic diseases remains a significant clinical problem. Recently, the addition of rhGH (recombinant human growth hormone) has permitted the modulation of healing. Although increasing numbers of papers are reporting the positive influence of GH on wound healing, some studies have rejected it. In fact, the side effects of systemic GH administration are not fully understood. This study attempts to examine the effect of topical and low-dose rhGH administration on skin wound healing.
Methods: Thirty male Wister rats weighing 250-400 g were chosen. They were anaesthetized and a full-thickness wound was created on their right flank.
Then they were randomized into cases (treated with topical rhGH applied to wound surface) and controls (given saline in isovolumic amount). Each rat was physically examined 7, 10, 14, 17 and 21 days after the operation and wound beds were qualitatively ranked. Differences between the control and case groups were analyzed. P values less than 5% were considered significant.
Results: There were no allergic reactions around the wound in the case group. We found the healing rate of the wounds to be significantly different between the two groups on all days (P values were 0.005, 0.008, 0.014, 0.025, and 0.046 on days 7, 10, 14, 17, and 21, respectively).
Conclusions: Skin healing was different in the two groups in this animal trial. We considered wound bed condition as the criterion for comparing the two groups. On days of examination, the differences between the groups were significant. The results showed the beneficial effect of GH on healing. We used very-low-dose topical rhGH which improved the healing process. The effects of long-term rhGH administration on human scarring remain undefined and further studies are required.

 
Keyword(s): RHGH (RECOMBINANT HUMAN GROWTH HORMONE), SKIN WOUND, HEALING
 
References: 
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