Paper Information

Journal:   IRANIAN JOURNAL OF NUCLEAR MEDICINE   2006 , Volume 14 , Number 26; Page(s) 28 To 34.
 
Paper: 

EVALUATION AND COMPARISON OF DIFFERENT QUALITY CONTROL METHODS IN RADIOCHEMICAL PURITY DETERMINATION OF NEW PEPTIDE KITS 99MTC- EDDA- TRICINE-HYNIC- TYR3-OCTREOTIDE AND 99MTC-EDDA-TRICINE- HYNIC- TYR3-OCTREOTATE FOR IMAGING SOMATOSTATIN RECEPTOR POSITIVE TUMORS

 
 
Author(s):  GANDOMKAR M.*, NAJAFI R.
 
* RADIOISOTOPE DEPARTMENT, NUCLEAR RESEARCH CENTER, ATOMIC ENERGY ORGANIZATION OF IRAN (AEOI), TEHRAN, IRAN
 
Abstract: 
Introduction: Using labeled peptides enjoys high importance in nuclear medicine. Somatostatin analogs labeled with different radionuclide are vastly investigated for diagnosis or treatment of somatostatin receptor positive tumors. Labeling somatostatin analogs with 99mTcas alternative of 111 In needs doing different quality control method for determination of labeling yield and complex stability for clinic applications.
Methods: For determining radiochemical purity, three different methods were compared and evaluated including HPLC, TLC and Sep-Pak.
Results: All the three methods were suitable for determining of radiochemical purity in peptide kits, although using HPLC was more effective rather than the others.
Conclusion: HPLC was the best method for determination of radiochemical purity of the peptide kits. TLC or Sep-Pak method should only be employed if HPLC is not available in nuclear medicine clinics, and after training and gaining sufficient operational experience.
 
Keyword(s): 99MTC, TYR3-OCTREOTIDE, TYR3-OCTREOTATE, QUALITY CONTROL, RADIOCHEMICAL PURITY
 
References: 
  • ندارد
 
  Persian Abstract Yearly Visit 53
 
Latest on Blog
Enter SID Blog