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Paper Information

Journal:   IRANIAN JOURNAL OF NUCLEAR MEDICINE   2006 , Volume 14 , Number 26; Page(s) 1 To 7.
 
Paper: 

EFFECTS OF DEPRESSION ON MYOCARDIAL PERFUSION SCINTIGRAPHY

 
 
Author(s):  ANSARI GILANI K.*, MODARESI ESFEH ZH., FALAHI B., SHAHID ZADEH MAHANI M.
 
* RESEARCH INSTITUTE FOR NUCLEAR MEDICINE, SHARITEI HOSPITAL, NORTH KAREGAR AVE., TEHRAN, IRAN
 
Abstract: 
Introduction: The relationship between depression and coronary artery disease is well established; however assessment of this relationship using functional and semi-quantitative imaging (myocardial perfusion scintigraphy) was lacking. The aim of this study was to assess the relationship between the severity of depression and the severity of myocardial perfusion abnormality.
Methods: Patients were assessed with rest/stress 99mTc-MIBImyocardial perfusion scintigraphy using Single Photon Emission Computed Tomography (SPECT) and Beck Depression Inventory (BDI-H). Visual and semi-quantitative assessment of myocardial perfusion score (MPS) in a five-scale measurement for standard 20-segment-model were used.
Results: When all patients (n=167) were evaluated, no correlation was found between MPS and BDI score. Considering only those with significant perfusion abnormality (MPS<90, n=38), negative correlation was found between MPS and BDI score (r= -0.641, p=0.017). Also higher BDI scores were recorded for patients with inferior wall infarction when compared with those with normal or near-normal MPS (MPS>95) (p=0.097), but other myocardial walls failed to show such association.
Conclusion: In patients with significant perfusion abnormality, the greater is this abnormality the more severe is the depression. Also patients with inferior wall infarction, have a higher BDI-score as compared with normal subjects.
 
Keyword(s): DEPRESSION, MYOCARDIAL PERFUSION, SCINTIGRAPHY
 
References: 
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