Paper Information

Journal:   DANESHVAR MEDICINE   JUNE-JULY 2007 , Volume 14 , Number 69; Page(s) 39 To 44.
 
Paper: 

CHANGE OF ANTIMICROBIAL RESISTANCE PATTERN AMONG CLINICAL ISOLATES OF SHIGELLA IN MASHHAD, DURING A TEN YEARS PERIOD

 
 
Author(s):  GHAZVINI K.*, MALEK JAFARIAN M., PARVINNIA L.
 
* DEPARTMENT OF MICROBIOLOGY AND VIROLOGY, SCHOOL OF MEDICINE, MASHHAD UNIVERSITY OF MEDICAL SCIENCES, MASHHAD
 
Abstract: 

Background: Shigella spp. is a common cause of diarrhea worldwide. Antimicrobial agents play an important role in treatment of Shigella enteritis. The treatment of shigellosis has been complicated by emergence of strains resistant to the commonly used antibiotics. The aim of the present study was to determine the sensitivity of Shigella strains to antibiotics usually used for the treatment of shigellosis and to survey the change of antimicrobial resistance of Shigella isolated in Mashhad, during a ten years period Materials & Methods: In this report, stool specimens were studied during 1992 to 1994 and 2002 to 2004. Isolation and identification of Shigella isolates was performed by standard methods and the serotype was determined according to the internationally accepted scheme. The disk diffusion method was applied for antimicrobial sensitivity testing against 12 antibiotics.
Results: Over these two periods, 81 cases of Shigella spp. were reported. Resistance to tetracycline, trimethoprim-sulfamethoxazole, streptomycin and chloramphenicol was common among the isolated Shigella. Comparing the antimicrobial susceptibility pattern of Shigella strains over these two periods, show that there was no significant increase in resistance to the antibiotics except for Kanamicin.
Conclusion: Widespread resistance of Shigella in present study indicates that empirical treatments of shigellosis are no longer useful and antibacterial susceptibility test are highly recommended.

 
Keyword(s): ANTIMICROBIAL RESISTANCE, SHIGELLA, DIARRHEA
 
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