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Paper Information

Journal:   DANESHVAR MEDICINE   JUNE-JULY 2007 , Volume 14 , Number 69; Page(s) 33 To 38.
 
Paper: 

EVALUATION OF RELATION BETWEEN LEARNING AND SENSITIVITY TO CHEMICAL KINDELING WITH PENTYLENETETRAZOLE IN MALE RATS

 
 
Author(s):  PALIZVAN M.R., GHAZNAVIRAD E.A.
 
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Abstract: 

Objective: In this research the correlation between impairment in spatial learning and kindling susceptibility was investigated.
Materials & Methods: 16 wistar male rats was trained for Morris water maze learning. One week after water maze learning, The rats were administered pentylenetetrazole [37.5 mg/kg, i.p] for induction of kindling and seizure stages were noted. Data were analyzed using correlation and Pearson test and the correlation between PTZ kindling and water maze learning was determaind.
Results: The results of the present study demonstrate that there are correlation between some of the seizure parameters such as seizure stage, stage 5 duration and number of stimulation required to produed stage 5 seizure in animals.
Conclusion: On the basis of the present data it is possible to predict the predisposing of male rats for kindling from the impairment of Morris water maze learning that indicate the abnormality in hippocampal neuronal circuits.

 
Keyword(s): MORRIS WATER MAZE LEARNING, KINDLING, HIPPOCAMPUS, PENTYLENE-TETRAZOLE
 
References: 
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