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Paper Information

Journal:   DANESHVAR MEDICINE   JUNE-JULY 2007 , Volume 14 , Number 69; Page(s) 27 To 32.
 
Paper: 

EFFECT OF CHRONIC ADMINISTRATION OF MATRICARIA CHAMOMILLA EXTRACT ON MORPHINE WITHDRAWAL SYNDROME IN ADULT MALE MICE

 
 
Author(s):  HONARVARAN F., KESMATI M., ESMAEILI M.H., JAHANI HASHEMI H., JAFARI H., ABBASI E.
 
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Abstract: 

Background: Several studies show that matricaria chamomilla extract can reduce pain, inflammation and anxiety. Therefore chronic administration of matricaria chamomilla extract may be useful for morphine withdrawal syndrome treatment Objective: To determine the effects of Matricaria Chamomilla extract on morphine withdrawal syndrome signs (MWS) in adult male mice.
Methods: 40 male mice divided in 2 groups control (saline) and morphine group. To develop morphine dependence, morphine group (n=8) was received morphine (s.c) for 4 days. (10,20 and 40 mg/kg Three times in day for 3 days and 40 mg/kg morphine in day 4) and divided in 4 sub groups. Three groups of them were received hydroalcholic extract of Matricaria chamomilla concurrently with each injection of morphine (MC extract was administrated in 3 different dose 10, 20, and 30 mg/kg). one group of them was received morphine only. Every mice were received 5 mg/kg naloxone, 3h after last injection of morphine in day 4 and then the frequencies of withdrawal behavior (jumping, climbing, rearing) and weight loss were assessed.
Findings: Data analysis showed that co-administration of Matricaria chamomilla reduced withdrawal sings in low administrated dose.
Conclusion: These results suggest that Matricaria chamomilla extract can attenuate withdrawal sings.

 
Keyword(s): ADDICTION, MORPHINE, WITHDRAWAL SYNDROME, MATRICARIA CHAMOMILLA, MICE
 
References: 
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