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Paper Information

Journal:   INTERNATIONAL JOURNAL OF RADIATION RESEARCH   FALL 2007 , Volume 5 , Number 2; Page(s) 53 To 61.
 
Paper: 

ACCELERATED PROLIFERATION CORRECTION FACTORS IN LINEAR-QUADRATIC AND MULTIPLE-COMPONENT MODELS

 
 
Author(s):  KEHWAR T.S.*, AKBER S.F., BHARDWAJ A.K., DANGWAL V.K.
 
* 30 MONTVIEW STREET, APT. #3, UNIONTOWN, PA 15401, USA.
 
Abstract: 
Background: Study in design to incorporate accelerated proliferation correction factors into linearquadratic and multiple-component models.
Materials and Methods: Accelerated proliferation rate correction factor has been incorporated into the linearquadratic and the multiple component models by applying accelerated exponential cell growth to explain the tumor cell kinetics and estimates proper treatment results. Biological effectiveness and tumor control probability, in terms of BED (LQ model), BRD (MC model), TCP(LQ model) and TCP(MC model), were computed for three conventional and two accelerated hyperfractionated radiation therapy treatment schedules with using a range of accelerated proliferation rate constants to demonstrate the effect of the proliferation process.
Results: The results of the study show that the accelerated proliferation rate reduces the effectiveness of a treatment schedule delivered in a prolonged period of time.
Conclusion: Care should be taken in the selection of a treatment protocol for a patient of head and neck cancer with an account of the cell kinetics of the tumor.
 
Keyword(s): ACCELERATED PROLIFERATION RATE, GROWTH FRACTION, TUMOR CONTROL PROBABILITY, LQ MODEL, MC MODEL
 
 
References: 
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Click to Cite.
APA: Copy

KEHWAR, T., & AKBER, S., & BHARDWAJ, A., & DANGWAL, V. (2007). ACCELERATED PROLIFERATION CORRECTION FACTORS IN LINEAR-QUADRATIC AND MULTIPLE-COMPONENT MODELS. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, 5(2), 53-61. https://www.sid.ir/en/journal/ViewPaper.aspx?id=102117



Vancouver: Copy

KEHWAR T.S., AKBER S.F., BHARDWAJ A.K., DANGWAL V.K.. ACCELERATED PROLIFERATION CORRECTION FACTORS IN LINEAR-QUADRATIC AND MULTIPLE-COMPONENT MODELS. INTERNATIONAL JOURNAL OF RADIATION RESEARCH. 2007 [cited 2021May13];5(2):53-61. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=102117



IEEE: Copy

KEHWAR, T., AKBER, S., BHARDWAJ, A., DANGWAL, V., 2007. ACCELERATED PROLIFERATION CORRECTION FACTORS IN LINEAR-QUADRATIC AND MULTIPLE-COMPONENT MODELS. INTERNATIONAL JOURNAL OF RADIATION RESEARCH, [online] 5(2), pp.53-61. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=102117.



 
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