Present investigation carried out to study different weed control methods in spring safflower under rain fed condition.The experiment was conducted in Sararood Research Station located in west of Iran in 2002. the experiment caried out in Mixed Factorial based on RCBD witht four replications. Factor A was included 4 different herbicides Trifluralin at 960 g a.i./ha, Pendimethalin at 660ga.i./ha, Ethalfluralin at 1172.5 g a.i./ha ,Imazametabenz at 625 g a.i./ha. and Factor B was 4 different method including without mechanical control, hand weeding at the 6 leaves stage, cultivator at 6 leaves stage, hand weeding at the 12 leaves stage + cultivator at 6 leaves stage along with two checks namely without weed, and without anyweed control. The results showed that according to analysis of variance weeds chemical control did not significant effect on seed yield but mechanical control had significant at %1 level on grain yield and dry matter and have not significant interaction of chemical and mechanical control have on yield and related traits of safflower so have not significant difference seed oil percent. Among mechanical methods that used, a hand weeding at 6 leaves stage had highest yield. According to standard method EWRS, effect soil application herbicides on weeds that exite on the area experiment have placed in poor degree and Imazametabenz herbicide in fair degree. With due attention to high plan, number of heads per plant and number of grain per plant safflower had the highest tolerance to Trifluralin and Imazamethabenz herbicides.