Paper Information

Journal:   JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE   2007 , Volume 29 , Number 57; Page(s) 31 To 36.
 
Paper:  EVALUATION OF THE EFFECT OF EPHEDERINE ON THE TIME OF BEGINNING OF THE EFFECT OF CISATRACORIUM
 
Author(s):  BI RASHK G., SALIMI A.R., OSTOVARI A.
 
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Abstract: 

Background: Aspiration is an important complication of general anesthesia and any delay in intubation could increase this risk. There are a few methods for rapid intubation. In this research we use combination of ephedrine and cisatracorium, in order to reduce onset time of cisatracorium.
Materials and Methods: In this randomized double blind controlled clinical trial research, 60 patients were divided in two groups. Blood pressure and pulse rate were measured before induction, 1 min after injection of ephedrine and 1, 3 and 5 mins after intubation. The onset of cisatracorium is measured by nerve stimulator by stimulation of adductorpollicis and TOF.
Results: There is no difference between measured blood pressure and pulse rates in two groups (p<0.001). Onset time of cisatracorium for the control group was 3.86
±0.6, and it was 2.89±0.6 for the case group. It shows statistical meaningful difference (p<0.001).
Conclusion: Low dose of ephedrine (70
mg/kg) during the induction of general anesthesia could reduce the onset of cisatracorium without any increase in blood pressure or heart rate.

 
Keyword(s): EPHEDRINE, ONSET OF MUSCLE RELAXANT, CISATRACORIUM
 
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