Paper Information

Journal:   JOURNAL OF IRANIAN SOCIETY ANAESTHESIOLOGY AND INTENSIVE CARE   2007 , Volume 29 , Number 57; Page(s) 37 To 43.
 
Paper: 

A DOUBLE BLINDED COMPARISON OF LIDOCAINE AND DIAZEPAM TO PREVENT FASCICULATION AND MYALGIA AFTER SUCCINYLCHOLINE

 
Author(s):  TAVAKOLI H., SHARIAT MOHARARI R., NAJAFI A., REZAEI J., ESFANDIARI KH., HASANI M.
 
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Abstract: 

Background: The aim of this study is the comparison of lidocaine and diazepam as a pretreatment to prevent or decline the fasculation and myalgia due to depolarizing muscle relaxant, succinylcholine.
Materials and Methods: 60 patients who had been chosen for small to moderate elective surgery were divided into 3 groups. Each group was 20 patients, and a double blinded controlled randomized prospective study was performed.
In group I, 0.1 mg/kg diazepam 5 min before induction, in group II lidocaine 1.5 mg/kg, 90 seconds befoere induction and in group III 3 ml normal saline, 3 min before induction was injectd. 120 seconds before intubation after administration of 15
mg/kg alfentanyl, induction was done with 3mg/kg Na-thiopental and 1.5 mg/kg succinylcholine. The presence and severity of pasciculation due to succinylcholine was recorded by an anesthesiologist who was unknown about the survey. The post operate myalgia was evaluated by the same anesthesiologist.
Results: Rate of fasciculation was significantly decreased in group I and II versus control group, but there was no difference in defasciulation between diazepam and lidocaine group (p-value=0.018).
Lidocaine decreased postoperative myalgia efficiently versus diazepam and normal saline, but this difference was not statistically significant among the groups.
Conclusion: Both lidocaine and diazepam have similar defasciulation effect, but it seems that lidocaine prevents myalgia more effectively than diazepam.

 
Keyword(s): SUCCINYLCHOLINE, DIAZEPAM, LIDOCAINE, FASCICULATION, MYALGIA
 
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