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Paper Information

Journal:   JOURNAL OF DIABETES AND METABOLIC DISORDERS   FALL 2007 , Volume 7 , Number 1 (22); Page(s) 9 To 22.
 
Paper: 

MINIREVIEW ON STRUCTURAL CHANGES OF GLYCATED HUMAN SERUM ALBUMIN

 
 
Author(s):  SATAR AHMADI N., MOUSAVI MOVAHEDI ALI AKBAR*
 
* BIOCHEMISTRY AND BIOPHYSICS RESEARCH CENTER, TEHRAN UNIVERSITY, TEHRAN, IRAN
 
Abstract: 

  The interaction of reducing carbohydrates with proteins leads to a cascade of reactions that are known as glycation or Maillard reaction that have important roles in diabetic complications. In this minireview, structural changes of glycated human serum albumin (GHSA) via various sugars in different incubation times, which reported in scientific literature as well as our research, were reported. Our studies showed glycation induced structural changes for Human Serum Albumin (HSA).  In glycation process of HSA after 21 days incubation, glucose separates from HSA and induced the formation of molten globule state that is relative to several diseases that originate from molten globule state in proteins. Also, glycation of HSA induced aggregation states and amyloid formation as well as decreased surface tension which plays a role of denaturant for protein as a surfactant. In following, we showed that alginate as a sugar polymer decreased glycation reaction in HSA. Finally, it is compared the structural changes of artificial and in vitro interaction of sugars with HSA as well as diabetic patients HSA. The results show the number of arginine residues in HSA of diabetic patients is more modified relative to lab samples. 

 
Keyword(s): GLYCATION, SERUM ALBUMIN, FIBRIL, MOLTEN GLOBULE, ALGINATE, CONFORMATIONAL CHANGES
 
 
References: 
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Citations: 
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+ Click to Cite.
APA: Copy

SATAR AHMADI, N., & MOUSAVI MOVAHEDI, A. (2007). MINIREVIEW ON STRUCTURAL CHANGES OF GLYCATED HUMAN SERUM ALBUMIN. JOURNAL OF DIABETES AND METABOLIC DISORDERS, 7(1 (22)), 9-22. https://www.sid.ir/en/journal/ViewPaper.aspx?id=101732



Vancouver: Copy

SATAR AHMADI N., MOUSAVI MOVAHEDI ALI AKBAR. MINIREVIEW ON STRUCTURAL CHANGES OF GLYCATED HUMAN SERUM ALBUMIN. JOURNAL OF DIABETES AND METABOLIC DISORDERS. 2007 [cited 2021June23];7(1 (22)):9-22. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101732



IEEE: Copy

SATAR AHMADI, N., MOUSAVI MOVAHEDI, A., 2007. MINIREVIEW ON STRUCTURAL CHANGES OF GLYCATED HUMAN SERUM ALBUMIN. JOURNAL OF DIABETES AND METABOLIC DISORDERS, [online] 7(1 (22)), pp.9-22. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101732.



 
 
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