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Paper Information

Journal:   JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)   FALL 2007 , Volume 11 , Number 3 (44); Page(s) 51 To 56.
 
Paper: 

HYPOTHYROIDISM AND TYPE 1 DIABETES MELLITUS

 
 
Author(s):  SHEYKH ALESLAMI H.*, ZIAEI A., DARVISH GHADERI S., VAHEDI S.
 
* 
 
Abstract: 

Background: Type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease.
Genetic susceptibility to autoantibody formation in association with autoimmune thyroid disease and type 1 diabetes mellitus has been described with varying frequencies.
Objective: To investigate the prevalence of anti-thyroid peroxidase (anti-TPO) and also the overt and subclinical hypothyroidism in type 1 diabetic patients.
Methods: In this case-control study, 65 subjects with type 1 diabetes mellitus and 65 unrelated normal controls were recruited for detection of anti-TPO and thyroid-stimulating hormone (TSH). Radioimmunoassay (RIA) was used for anti-TPO and TSH detection.
Findings: Out of 65 type 1 diabetic patients, 18 (27.7%) were positive for anti-TPO and 18 (27.7%) with abnormal serum TSH level. Among the patient group, 11 (16%) were found to have overt hypothyroidism and 7 (10.8%) with subclinical hypothyroidism. The mean anti-TPO levels were higher in patients with overt hypothyroidism (238.18±223.69 U/ml) than in patients with subclinical hypothyroidism (36.38±22.46 U/ml). Of a total of 11 patients with overt hypothyroidism, 9 (81.1%) showed abnormal anti-TPO levels, whereas positive anti-TPO was detected in 57% (4 out of 7) of patients with subclinical hypothyroidism.
Conclusion: The presence of anti-TPO in 27.7% of type 1 diabetic patients confirmed a strong association between autoimmune thyroid disease and type 1 diabetes mellitus. Thus, for early detection of autoimmune thyroid disease in patients with type 1 diabetes mellitus, the measurement of anti-TPO and TSH, preferably at the onset of disease, is recommended.

 
Keyword(s): TYPE 1 DIABETES MELLITUS, HYPOTHYROIDISM, ANTI THYROID PEROXIDASE ANTIBODY
 
 
References: 
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Citations: 
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APA: Copy

SHEYKH ALESLAMI, H., & ZIAEI, A., & DARVISH GHADERI, S., & VAHEDI, S. (2007). HYPOTHYROIDISM AND TYPE 1 DIABETES MELLITUS. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 11(3 (44)), 51-56. https://www.sid.ir/en/journal/ViewPaper.aspx?id=101720



Vancouver: Copy

SHEYKH ALESLAMI H., ZIAEI A., DARVISH GHADERI S., VAHEDI S.. HYPOTHYROIDISM AND TYPE 1 DIABETES MELLITUS. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES). 2007 [cited 2021June24];11(3 (44)):51-56. Available from: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101720



IEEE: Copy

SHEYKH ALESLAMI, H., ZIAEI, A., DARVISH GHADERI, S., VAHEDI, S., 2007. HYPOTHYROIDISM AND TYPE 1 DIABETES MELLITUS. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), [online] 11(3 (44)), pp.51-56. Available: https://www.sid.ir/en/journal/ViewPaper.aspx?id=101720.



 
 
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